This Project Grant award, valued at $1,192,612 and awarded by the National Institute on Drug Abuse (NIDA), supports a research initiative to integrate HIV prevention services into clinical care settings for people with opioid use disorder (OUD). The project aims to address the public health crisis of opioid use and the higher risk of HIV infection among those with OUD. Key elements of the study include: Analyzing healthcare utilization data to assess OUD patients' engagement with HIV...
This Project Grant award of $815,779 from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 Drug Use and Addiction Research Programs, supports a comprehensive study to characterize the real-world care pathways utilized by patients with substance use disorder (SUD) within a large integrated healthcare system. The study aims to: Apply multi-state Markov models to empirically observe the longitudinal transitions in SUD care, including the types of interventions and settings...
This $2,314,854 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a network-based study to evaluate the spillover effects of HIV interventions among marginalized populations that use illicit substances. The project will leverage existing data from three network studies in Chicago to develop new statistical and modeling approaches for assessing the spillover of HIV interventions, such as...
This Project Grant award of $677,250.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund the development and testing of the Healthcare Empowerment and Advocacy for Recovery from Trafficking (HEART) intervention. The goal is to engage women with experiences of sex trafficking or vulnerability to sex trafficking into comprehensive care services, including HIV, substance use disorder, mental health, and social services....
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will test the effectiveness of an adapted version of Cognitive Processing Therapy (CPT-CJ) for reducing post-incarceration drug use, mental health symptoms, and drug-related crime among justice-involved individuals in 10 prisons across 5 states. The $2,663,022 grant, awarded to the University of Arkansas for Medical Sciences (UAMS), will also evaluate...
TARGETED SMALL MOLECULE RECRUITMENT TO SUPPRESS THE HIV TRANSCRIPTIONALLY ACTIVE RESERVOIR - PROJECT SUMMARY/ABSTRACT ANTIRETROVIRAL THERAPY (ART), INTRODUCED NEARLY 40 YEARS AGO, CAN DURABLY SUPPRESS HIV REPLICATION BUT FAILS TO TARGET THE LATENT RESERVOIR COMPOSED OF RESTING CD4+ T CELLS AND MYELOID CELLS, SUCH AS MICROGLIA IN THE BRAIN. THE INTERTWINED NATURE OF HIV AND SUBSTANCE USE DISORDER (SUD) EXACERBATES THIS ISSUE, AS ADDICTIVE SUBSTANCES INCREASE THE RISK OF HIV ACQUISITION,...
This Project Grant award for $719,401, provided by the Trans-NIH Research Support program (CFDA 93.310) of the National Institutes of Health (NIH) Office of the Director, will fund the development and evaluation of novel methods to predict, detect, and diagnose outbreaks of HIV and other infectious diseases among people who use drugs (PWUD). The key products and services to be delivered under this 5-year award include: Developing and evaluating modeling and pattern-recognition frameworks to...
The National Institute on Drug Abuse (NIDA) awarded a $375,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Johns Hopkins University to evaluate the impact of a status-neutral, person-centric intervention in New Delhi, India on HIV incidence, viral suppression, and mortality among people who inject drugs (PWID). The project aims to 1) assess the direct impact of the intervention on PWID in New Delhi, 2) investigate the diffusion of the intervention over...
This $672,206 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to increase HIV and substance use prevention and treatment for adolescent and young adult (AYA) sexual violence survivors. The key activities include: Tailoring existing Sexual Assault Nurse Examiner (SANE) services to incorporate same-day HIV prophylaxis and substance use prevention, informed by interviews with 20 AYA survivors and 20 key...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to investigate the intersection of HIV infection and opioid use on inflammation and neurotoxicity in the central nervous system. The 5-year study aims to analyze brain tissue samples from persons living with HIV and persons without HIV to determine the relationship between HIV activity,...