Project Grant DP2AI201031
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $1,999,706 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support the ImmGen Consortium's immunological research through August 31, 2031. The award funds dissection of gene expression and regulation across all immune system cell lineages through shared data generation pipelines. Specific deliverables include broadening immune transcriptomes...
- The National Institute of Allergy and Infectious Diseases awarded $414,029 to the President and Fellows of Harvard College on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research into programmed ribosomal frameshifting in coronaviruses. The research aims to gain structural and mechanistic understanding of how coronaviruses regulate gene expression through a minus-one frameshifting event that allows the ribosome to bypass a stop codon and...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $835,269 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on cytokine regulation of lymphocyte trafficking. The project investigates how high endothelial venules (HEV)—specialized microvessels in secondary lymphoid organs—form and function, with emphasis on the role of endothelial CD130 signaling in HEV formation and...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital Corporation (Boston Children's Hospital) $794,886 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of endogenous chimeric mRNA-encoded gasdermin D fusion proteins in pyroptosis and innate immunity. The research employs long-read direct RNA sequencing to identify and characterize chimeric mRNA (chRNA) species in mammalian cells, with focus...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $295,750 on May 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to benchmark single-lineage RNA-seq (SLRNA-SEQ), an innovative technology for transcriptome analysis of microbial lineages with sensitivity exceeding current single-microbe methods. The award funds development and validation of SLRNA-SEQ using capsules with amphiphilic gel envelopes (CAGES) to...
- The National Institute of Allergy and Infectious Diseases awarded New York University $153,560 on December 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct rational rewriting of the mouse interferon-alpha/beta (IFN-I) locus for functional characterization. The funded work uses large-DNA assembly and delivery techniques to rewrite the entire IFN-I locus in mouse embryonic stem cells. The project has established the first complete IFN-I knockout mouse...
- The National Institute of Allergy and Infectious Diseases awarded $864,475 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds basic structural and functional research on coronavirus spike proteins in membrane environments. The funded work examines distinct conformational states of membrane-bound spike proteins reconstituted in lipid bilayers, with focus...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) $228,000 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to determine the role of micronutrient deficiency in immune response to oral rotavirus vaccine in low-resource settings. The research evaluates associations between four key micronutrients—iron, zinc, vitamin A, and vitamin D—and infants' failure to...
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College $916,436 through CFDA 93.855 (Allergy and Infectious Diseases Research) on February 5, 2026, to engineer ex vivo thymic tissue capable of supporting functional human T cell development from induced pluripotent stem cells for immunotherapies. The research combines iPSC-derived lymphoid progenitors with engineered biomaterials that recapitulate thymic microarchitecture, addressing current...
- The National Institute of Allergy and Infectious Diseases awarded The General Hospital Corporation (Massachusetts General Hospital) $661,313 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support development of a pan-influenza A vaccine. The research, led by Dr. Daniel Lingwood at the Ragon Institute of MGH, MIT and Harvard, focuses on elicitation of broadly neutralizing antibodies that protect against all influenza A viruses by triggering...
The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College $456,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop SUPERSCAN, a synthetic-DNA-enabled screening platform to decode the sequence-function relationship of human interferons (IFNs) and engineer next-generation variants with optimized antiviral potency and reduced autoantibody susceptibility. The research addresses a critical gap in innate immunity therapeutics. The human genome encodes 22 distinct interferons with multiple alleles and polymorphisms, yet their functional rules—governing antiviral potency, duration, and inflammatory cost—remain poorly understood. The investigator's prior collaboration with Jean-Laurent Casanova at Rockefeller University found that autoantibodies neutralizing type I IFNs account for approximately 15% of critical COVID-19 pneumonia cases and approximately 20% of related deaths, while recessive inborn errors of interferon immunity explain approximately 10% of pediatric COVID-19 hospitalizations and cause severe reactions to live-attenuated vaccines. SUPERSCAN preserves genotype-phenotype linkage through spatial separation during secretion, enabling precise, time-resolved measurements of antiviral activity, inflammatory signaling, cell viability, and autoantibody susceptibility. Aim 1 will build the first systematic functional atlas of human interferons and their natural variants. Aim 2 will engineer next-generation IFN-L3 variants with optimized potency and safety. Aim 3 will map the combinatorial effects of interferon variants on immune outcomes. Work is performed in Boston, Massachusetts, with a period of performance through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $456.0k | 7/30/26 |