Project Grant DP2AI200956
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $100,228 on November 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate G-protein signaling mechanisms in Aspergillus fumigatus colony morphology and aerobic glycolysis. The research employs CRISPR-Cas9 genetic techniques to explore epistatic relationships between BAFA, GPAA, G-protein coupled receptors, and H-morph colony morphology in the pathogenic...
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic $232,500 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and deploy multiplexed reporter platforms for mapping interactions between bile acid pools and nuclear receptors. The funded work builds multiplex nuclear receptor reporter systems capable of identifying ligand-receptor binding across all 48 human nuclear receptors using physiologically...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded Trustees of Dartmouth College $717,139 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a computational platform identifying clinically effective T-cell receptors (TCRs) for infectious diseases based on receptor sequences provided by users. The platform identifies TCRs putatively capable of...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $233,125 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and validate a toolkit for studying 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) as a driver of metabolic adaptation in bacterial pathogens. The research targets bacterial central metabolism as a route to novel antibacterial strategies, focusing on how pathogens remodel their metabolism to...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $100,228 on February 4, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of alveolar macrophage mitochondria and peroxisomes in antifungal immune responses against Aspergillus fumigatus infections. The research addresses how mitochondria and peroxisomes regulate interferon type I and III production in alveolar macrophages exposed to the fungal...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $158,190 on December 20, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate dual functions of an effector immunity protein in Pseudomonas aeruginosa biofilm biogenesis. The research tests the hypothesis that TSIT, a Type VI secretion system immunity protein in P. aeruginosa, functions as both a traditional T6SS immunity protein and as a transcription factor...
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic a cooperative agreement of $561,873 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on bile acid control of commensal-specific immune responses. The funded research investigates how bile acids—gastrointestinal metabolites with dual roles in lipid absorption and cell signaling—dynamically engage nuclear receptors and GPCRs to modulate...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $148,614 to Massachusetts Institute of Technology on January 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop glycopolymers designed to enhance interactions between immune cells and pathogenic bacteria, creating "cellular glues" that leverage the body's innate immune mechanisms as an alternative to...
- The National Institute of Allergy and Infectious Diseases awarded $825,054 to Trustees of Dartmouth College on February 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how a dual-function Type VI secretion system immunity protein affects airway microbiota composition and pathogen fitness. The research examines the T6SS effector TSET and its cognate immunity protein TSIT in Pseudomonas aeruginosa, which causes chronic respiratory infections in...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $630,677 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Aspergillus fumigatus persistence within alveolar macrophages and its role in driving chronic aspergillosis. The research addresses host-pathogen interactions that enable persistent fungal infection in the lungs, particularly in people with cystic fibrosis (PWCF) who develop allergic...
The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $458,854 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop genome-scale fluxomics technology for measuring metabolic reprogramming in human pathogens during infection. The project addresses two barriers to routine genome-scale application of fluxomics: the labor-intensive manual data processing demanded by current isotope-tracing workflows and the limitation of metabolic flux analysis to small networks. The recipient will automate mass spectrometry data processing to compute mass isotopologue distributions for all detected metabolites through untargeted profiling and develop a scalable framework integrating isotope-tracing data with multi-omics data to infer reaction rates at genome scale. These genome-scale flux measurements are intended to provide direct, quantitative measurement of metabolic reaction rates across entire networks, revealing how metabolic networks are dynamically reprogrammed during pathogenic infection and enabling identification of accurate metabolic targets for anti-virulence strategies. Performance occurs in Hanover, New Hampshire, with a period of performance from August 4, 2026, through July 31, 2031. This is a project grant, the assistance type under which the NIH funds research projects addressing specific scientific objectives through competitive peer review.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.9k | 8/4/26 |