The National Institutes of Health Office of the Director awarded $2,907,000 under the Trans-NIH Research Support program to the Regents of the University of California, San Francisco for a project grant titled "Discovering Mechanisms of Tissue-Resident Immune Aging." The grant will fund research from September 2022 through August 2025 to study the mechanisms driving dysregulation of the aging adipose tissue-resident immune compartment. Specifically, the researchers will use inducible fate-mapping and intra-vascular labeling techniques to track long-lived adipose tissue immune cells over the lifespan. They will also employ a viral vector-based proximity ligation approach to identify age-dependent changes in adipose secreted proteins and their impacts on resident immune cells. Comparing old and young obese mice, the project aims to isolate age-specific mechanisms of inflammation and adipose tissue dysfunction. Results will inform strategies to protect the aging adipose immune system and prevent inflammation.
Generated 1/6/24, 11:57 AM