Project Grant DESC0020511

This three-year, $1,368,422 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports the development of cryogenic electron microscopy (cryo-EM) to study phase separation in lipid membranes. Frederick A. Heberle of the University of Tennessee and M. Neal Waxham of the University of Texas Health Science Center at Houston will optimize cryo-EM imaging techniques to visualize nanoscale lipid raft domains in cell membranes. Goals include...

This two-year, $219,836 National Science Foundation Integrative Activities Project Grant supports training in cryogenic electron microscopy (cryo-EM) for researchers at the University of Nebraska-Lincoln. The grant enables a research team to acquire hands-on cryo-EM training from experts at the Pacific Northwest Center for Cryo-EM, a user facility operated by Oregon Health & Science University and Pacific Northwest National Laboratory. Upon completing the training, the researchers will...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant provides $274,771 to H-Bar Instruments, LLC to develop a novel liquid helium transmission electron microscope (TEM) specimen holder. The holder will enable atomic-scale imaging of materials and devices at temperatures as low as 10 Kelvin, overcoming limitations of current low-temperature TEM capabilities. The project aims to create a commercially viable instrument that can turn any TEM...

This $100,000 Project Grant from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program will support the development of a transmission electron microscope specimen holder for imaging quantum matter and other extreme low-temperature applications at the University of Michigan. The specimen holder aims to enable atomic resolution imaging of materials at or near their operating temperatures, including quantum devices and materials used in quantum...

This $2,000,000 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of a Thermo Scientific Glacios 200 kV Cryo-Transmission Electron Microscope (Cryo-TEM) at the University of Iowa. The Cryo-TEM instrument will be housed in the university's Protein and Crystallography Facility to support biomedical research by providing high-resolution macromolecular structure determination...

The University of North Carolina at Chapel Hill received a $2.0 million Project Grant from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to acquire a JEOL JEM-CRYO ARM300 (JEM-3300), a 300 kilovolt (kev) cryogenic-transmission electron microscope (cryoTEM). The award, obligated on August 1, 2025, with a completion date of July 31, 2026, will establish this instrument at UNC-CH's cryoEM Core facility to support high-resolution...

This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...

Sindri Materials Corp received a $306,872 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with completion targeted by July 31, 2026. The company will develop an optimized graphene-based cryo-electron microscopy (cryo-EM) device architecture utilizing its proprietary ultra-high-quality graphene production technology to address current limitations in sample preparation...

This Project Grant from the National Science Foundation's Integrative Activities program totaling $154,755 will enhance structural science capacity in the Rocky Mountain Northwest region through microcrystal electron diffraction training. The University of Montana will provide comprehensive microcrystal electron diffraction analysis instruction and experience to the principal investigator and two trainees from remote learning and collaborative visits to the National Center for Cryo-Electron...