Project Grant DESC0006191

This $1,373,044 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the Massachusetts Institute of Technology to develop microbial strains with minimal genomes for integrated bioprocessing using supercritical carbon dioxide. The goal is to elucidate the genotype-phenotype relationship of tolerance to supercritical CO2 for a selected microorganism and construct a reduced genome strain displaying the desired tolerance phenotype....

Ometa Labs LLC received a $675,609 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop an advanced bioinformatics platform for large-scale untargeted metabolomics analysis. The award, effective August 1, 2025 through July 31, 2027, will support the rebuilding and enhancement of existing software to enable repository-scale identification and characterization of small molecule...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 provides funding to Clue Genetics Inc. for the development of a fungi-focused metabologenomics platform for natural product discovery. The key products and services to be delivered under this 1-year Phase I SBIR project include: Annotating biosynthetic gene clusters (BGCs) from 200 genomes selected from a diverse set of bioactive fungi to uncover new drugs,...

Federal Project Grant Award Summary Chemia Biosciences, Inc. received a $781,502 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop NatDiscovery, a computational platform for identifying novel non-ribosomal peptides from complex mass spectrometry datasets. The award, effective July 1, 2025 through June 30, 2028, supports the integration of genome mining with computational...

Federal Project Grant Award Summary The University of Minnesota's Office of Sponsored Projects Administration received a $423.5K Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2026, with completion targeted for February 28, 2031. The TERPENE project—Titer Enhancement via Refactored Precursor Pathways for Natural Produce Discovery—addresses critical bottlenecks in natural...

This $656,664 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Miami University from August 2022 through July 2025 to develop microbial strains with minimal genomes for integrated bioprocessing applications. The goal is to elucidate the genotype-phenotype relationship of tolerance to supercritical carbon dioxide in a selected microorganism using a reduced genome approach. Researchers will construct transposon libraries to...

This three-year, $387,240 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support improvements to FAPROTAX, a popular database and computational tool for predicting the metabolic functions encoded by prokaryotic taxa in microbiome surveys. FAPROTAX2 will incorporate additional experimental evidence from literature, redefine metabolic functions consistently with the Metacyc pathway database, include phenotypic data from thousands of...

Federal Project Grant Award Summary Vivid Bioinnovations, PBC (operating as Fluid Discovery, Inc.) received a $306,872 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period August 1, 2025 through July 31, 2026. The award supports development of a commercial prototype for an ultrahigh-throughput biocatalyst evolution platform that combines precision nanoliter fluid handling, label-free...

Federal Grant Award Summary Syntaxisbio Inc. received a $396,170 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) to develop novel technologies for cellular age profiling and validation. The project, which commenced on September 17, 2025, and is scheduled for completion by August 31, 2026, aims to address the critical challenge of reliably identifying cell line age and passage history in biomedical research. The...

Federal Grant Award Summary Newomics Inc. received a $1.0 million Small Business Innovation Research (SBIR) Phase II Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2027. The award funds the development and commercialization of the UniESI platform, an integrated imaging-mass spectrometry front-end system designed for native spray mass...