The University of Georgia Research Foundation, Inc. was awarded a $750,000 Project Grant from the Environmental Protection Agency Office of Research and Development's Science to Achieve Results (STAR) Research Program to develop a Quantitative Adverse Outcome Pathway (QAOP) network for assessing developmental neurotoxicity of per- and polyfluoroalkyl substance mixtures. Leveraging the nematode Caenorhabditis elegans as an invertebrate in vivo model, the Foundation will construct an environmentally relevant per- and polyfluoroalkyl substance reference mixture, evaluate developmental neurotoxicity of individual substances and the mixture, and perform whole mixture assessments in water samples. Annual and final reports on progress and findings will be delivered to the EPA, along with the newly developed QAOP network integrated with C. elegans and supporting statistical models. This research aims to advance the EPA's understanding of mixture-based hazard and dose-response assessments for substances that simultaneously or sequentially expose human and environmental health. No subawards are included in the Project Grant awarded September 1, 2022 for completion by August 31, 2025.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $750.0k | 7/5/22 |