Project Grant 84045001

The U.S. Environmental Protection Agency (EPA) awarded $750,000 under the Science to Achieve Results (STAR) Research Program to Texas A&M University for a three-year project grant concluding in August 2025. The goal of the project is to develop a tiered hybrid experimental-computational strategy for rapid risk assessment of complex environmental mixtures and unknown variable composition substances. Key products and services include evaluation of chemical mixture compositions and hazards through integration of toxicological, analytical, and modeling methods. Texas A&M will group mixture components for hazard assessment using bioactivity data from human induced pluripotent stem cell-derived cells, prioritize components most likely to contribute to joint toxicity, and predict mixture toxicity through probabilistic additivity models. North Carolina State University will receive a subaward to contribute statistical modeling and analysis, including maintenance of phenotype and exposure data for investigators. Annual and final reports detailing methods and tools for rapid characterization of environmental mixture composition and hazards will be delivered.