The National Institute of Standards and Technology (NIST) awarded a $963,000 Project Grant under the Congressionally-Identified Projects program (CFDA 11.617) to the University of Maryland, Baltimore (UMB) for the period of October 1, 2024 to September 30, 2026. The purpose of this grant is to accelerate structure-based drug and vaccine design programs that benefit human health by implementing state-of-the-art electron detection hardware to determine 3D structures of various biological compounds at atomic resolution using cryogenic electron microscopy (cryoEM). Specifically, UMB will upgrade its high-resolution cryoEM with a direct electron detector to enable faster detection speed, improved spatial resolution, better stability, and increased radiation hardness. This will significantly improve throughput for imaging and tomographic studies to support numerous biomedical applications, including the optimization of a new class of anticancer agents, examination of the vitamin A transporter STRA6, and collaboration with industry partners to bring new discoveries to the clinical level and improve biomanufacturing protocols. The primary beneficiary of this effort is human health through the development, optimization, and implementation of diverse drugs, proteins, and other biomolecules for therapeutics, vaccines, and modern/preventive medicines.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $963.0k | 9/9/24 |