The National Science Foundation Division of Social and Economic Science awarded the University of Virginia $210,470 on October 1, 2025, under the Social, Behavioral, and Economic Sciences program (CFDA 47.075) to conduct a collaborative analysis of disruptions in the global science system. The research examines how non-science isolation practices, restrictive measures, and geopolitical shifts affect international scientific collaboration, researcher mobility, and resource exchange. The project employs quasi-experimental designs utilizing three recent global events as cases to investigate the causal impact of disengagement from the integrated global scientific community on scientific development. The researchers apply causal inference techniques—specifically the synthetic control method and difference-in-differences analysis—to measure changes in scientific publication production and the exchange of scientific capital, including funding resources and researcher mobility. The project constructs a comprehensive dataset incorporating international publication and mobility records to address potential biases in existing international databases. The work is performed in Charlottesville, Virginia, with a period of performance through July 31, 2027. The findings serve to inform strategic decision-making in the governance of scientific activities and help policymakers understand how to maintain U.S. leadership in global scientific research and innovation within an increasingly complex geopolitical landscape.