Project Grant 2603593
- This Project Grant award from the National Science Foundation's Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) is providing $399,997 to the University of Washington to advance hydrogen/deuterium exchange mass spectrometry (HDX-MS) for studying protein structure and dynamics. The key objectives are to: 1) develop internal standards to improve the reproducibility of HDX-MS measurements, 2) create software tools for more robust analysis of HDX-MS data to better detect...
- The National Science Foundation Division of Chemistry awarded the University of Washington $588,303 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop computational methods and experimental techniques for ion mobility–mass spectrometry that advance the measurement of protein and molecular structures and dynamics. The research group will create fast computational methods for interpreting ion mobility–mass spectrometry measurements and introduce a new...
- The National Science Foundation Division of Chemistry awarded the University of Washington $479,403 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop and optimize mass spectrometry methods for characterizing complex glycoproteins and their heterogeneous glycosylation states. The project will advance ion-ion reactions and tandem mass spectrometry instrumentation through combinations of collision-, electron-, and photon-based gas-phase activation,...
- The National Science Foundation Division of Chemistry awarded a $1,010,000 project grant to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing intact proteins through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jenny Brodbelt and her research group will apply ultraviolet photodissociation and other dynamic ion manipulation strategies to amplify structural and post-translational modification details...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program, provides $551,717 in funding to the University of Washington for a 3-year project period from August 1, 2024 to July 31, 2027. The project, led by Professor Frantisek Turecek, focuses on developing new chemical reactions for crosslinking biomolecular ions representing components of proteins and nucleic acids. The research...
- This $390,000 National Science Foundation Project Grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), will support the development of Absolute Quantitative Protein Footprinting Mass Spectrometry (AQPFMS) for probing protein three-dimensional structures. Professor Hao Chen of the New Jersey Institute of Technology and collaborator Xiaolin Cheng of Ohio State University will refine an approach using AQPFMS to provide quantitative analysis of solvent-accessible...
- The National Science Foundation (NSF) awarded a $348,398 Project Grant to researchers at the University of California, Los Angeles (UCLA) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The grant supports computational studies aimed at improving the understanding and outcomes of covalent labeling mass spectrometry (MS) measurements. Specifically, the researchers will perform molecular dynamics simulations to better model how covalent labeling reagents interact...
- The National Science Foundation (NSF) Division of Chemistry awarded a $348,737 Project Grant to Mississippi State University to acquire a high-resolution quadrupole time-of-flight mass spectrometer with diverse inlet and ionization capabilities for chemical analyses. This award is jointly funded through the Major Research Instrumentation Program, Chemistry Research Instrumentation Program, and Established Program to Stimulate Competitive Research. The new instrument will strengthen the...
- The National Science Foundation (NSF) awarded a $599,879 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of South Florida (USF). The grant, effective from August 1, 2024 to July 31, 2029, supports Professor Wenqi Liu's research on utilizing hydrogen bonding for molecular recognition in water. The project aims to develop synthetic receptors that can effectively use hydrogen bonding, a capability that has been challenging for previous synthetic...
- The National Science Foundation (NSF) Division of Chemistry awarded a 3-year, $389,999 Project Grant to Florida State University (FSU) under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new approaches to characterize the structural dynamics of proteins that play critical roles in chemical reactions within biological cells. The project, led by Dr. Christian Bleiholder, will combine and enhance the capabilities of tandem-ion mobility spectrometry coupled with mass...
The National Science Foundation Division of Chemistry awarded the University of Washington $429,336 on August 15, 2026, to develop residue-specific resolution hydrogen/deuterium exchange with mass spectrometry (HDX-MS), a bioanalytical technique for characterizing protein structure and binding interactions. The project, funded under the Mathematical and Physical Sciences program (CFDA 47.049), runs through July 31, 2029, and is performed in Seattle, Washington. Current HDX-MS methods operate at peptide-level resolution, limiting their ability to characterize protein behavior and function with inter-lab reproducibility. This work will adopt emerging mass spectrometry fragmentation strategies—electron transfer dissociation and ultraviolet photodissociation—combined with software development to achieve direct measurement of hydrogen exchange at the single amide-residue level. The enhanced resolution will reduce hydrogen migration artifacts that currently delocalize critical exchange information and will streamline both data acquisition and analysis workflows. These advances will provide researchers a more comprehensive tool for protein characterization during therapeutic discovery and development stages. The project includes graduate and undergraduate student engagement in research training.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.3k | 8/14/26 |