Project Grant 2546314
- This National Science Foundation Project Grant of $299,785 will fund research into the integrated effects of mechanical and biochemical factors on breast tumor invasion and metastasis. Awarded on September 1, 2022 under the Engineering program (CFDA 47.041), the grant supports a collaborative research project led by the University of Michigan from September 1, 2022 through August 31, 2025. Specifically, the research team will develop quantitative imaging biosensors and tissue-engineered breast...
- This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports a research program at Michigan State University to study the active tensioning response of epithelial cells under sustained strain. The $489,874.00 award, effective from October 1, 2025 through September 30, 2028, aims to characterize the tensioning phenomena in epithelial cells and delineate the underlying mechanosensing mechanisms that mediate this stress response. The...
- The U.S. National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $400,000 project grant to Michigan State University (MSU) to develop improved computational imaging methods for tomographic applications. The 3-year project, starting September 1, 2025, aims to create novel combinations of conventional physical models and AI-based models to generate quantitatively accurate and reproducible images from limited or scatter-corrupted measurement setups. This research seeks to...
- The National Science Foundation (NSF) awarded a $360,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Alabama to develop a biomimetic 3D engineered model incorporating innate immune cells (i.e., macrophages, microglia) to study drug resistance in brain metastatic breast cancer (BMBC). The goal is to use this model to investigate how microglia and macrophages influence BMBC cell characteristics and response to treatment. The project aims to contribute to training...
- This $391,764 Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) to Purdue University will fund the development of a "cell radar speed gun" using laser and biophotonics technology to measure the speed and density of cells, including cancer cells and immune cells, as they move through living tissues. The goal is to enable more accurate assessment of the benefits of immunotherapies for cancer treatment by providing detailed information on cell movement...
- This $200,000 National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Clarkson University will develop a novel near-infrared (NIR) mechanochemical biophotonic platform for deep-tissue biomedical imaging. The project aims to create a breakthrough technology that combines ultrasound waves and NIR light to enable high-resolution, 3D imaging of molecular and sub-cellular structures deep within the body. This approach seeks to address limitations of existing imaging...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a collaborative research project focused on studying the mechanics of tissue boundary formation. The $400,000 award, with a performance period from September 1, 2025 to August 31, 2028, will be used by researchers at the University of Michigan to investigate how mechanical forces inside the body help shape developing tissues during early stages of life. The project aims to combine...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded Georgia Tech Research Corp a $861,467 Project Grant to develop and implement a new super-resolution imaging technique called Parallel Multifocal Scanning (PMS) Microscopy. The research aims to create an advanced biophotonics and microscopy platform that can provide sub-diffraction limited resolution, confocal-like optical sectioning, and enhanced contrast for studying cells and tissues with...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $500,000.00, with a period of performance from October 1, 2025 to September 30, 2028, is for the development of a wearable, real-time 3D ultrasound system optimized for wide-angle, high-resolution volumetric imaging of the breast. The system is intended to improve access to early breast cancer detection, particularly for individuals with dense breast tissue or limited imaging access, by serving as...
- This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $437,093 to Michigan State University aims to develop a novel optical imaging technology called Photoacoustic-Brillouin Microscopy (PABM) to quantify the mechanical properties of cancer cells and their microenvironment in a non-contact, non-invasive, and high-resolution manner. The goal is to better understand the relationship between the altered mechanics of tumor tissue and the progression of metastatic cancers. In addition to the research objectives, the project will also develop educational modules to promote the dissemination of the PABM technology and stimulate interest in biophotonics among high school, undergraduate, and graduate students. The award period is from November 15, 2025 to October 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.1k | 12/1/25 |