Project Grant 2545054
- Purdue University was awarded a three-year, $1,002,041 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from August 2021 through July 2024 to elucidate the interplay between two chromatin regulators, HDA8 and ELP3, in dynamically controlling primary and secondary metabolic networks in plants. As part of the Biological Sciences program's goal to...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
- This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) supports research at Michigan State University to investigate the metabolic pathways that plants use to produce diverse aromatic compounds from carbon fixed during photosynthesis. The $823,311 award, effective June 1, 2024 through May 31, 2027, aims to quantify carbon fluxes through the Calvin-Benson cycle and parallel shikimate and non-shikimate biosynthetic pathways that lead to aromatic...
- This Project Grant award of $1,100,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research at the University of California, Davis to study the genetic and chemical processes behind the diversity of specialized metabolites in plants. The project will investigate the key biosynthetic genes and modifications that create a range of glucosinolate compounds in the Brassicales plant family, which contribute to the flavors, aromas, and health benefits...
- Federal Grant Award Summary Purdue University received a $399,531 Project Grant from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074) to investigate the molecular mechanisms governing meristem development in fern gametophytes and sporophytes. The project, which commenced September 1, 2025 and concludes August 31, 2027, will identify key regulatory factors that control the formation and maintenance of specialized...
- Summary Purdue University received a $1.16 million Project Grant from the National Science Foundation's Division of Emerging Frontiers under the Biological Sciences program (CFDA 47.074) effective September 1, 2025, through August 31, 2028. This collaborative research initiative investigates actin-mediated mechanical stress sensing and the control of epidermal tissue integrity in plants. The project delivers fundamental research outputs including experimental measurements of tissue mechanical...
- This Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $2,999,526 to Michigan State University to expand the Plant Metabolic Network (PMN) database and establish a plant enzyme function consortium. Key products and services to be delivered include: Expanding the PMN database from 126 to over 1,000 plant species by leveraging bioinformatics tools to rapidly create new PMN databases. This will provide researchers greater access to metabolic...
- Federal Project Grant Award Summary MIT received $1,041,774 in funding from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a collaborative research project running from August 1, 2025, through July 31, 2029. This project grant supports fundamental research investigating analog information storage in chromatin states, with the goal of understanding how cells encode and maintain their identity through...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded The Washington University a Project Grant totaling $1,115,181 (Award Date: July 1, 2025; Completion Date: June 30, 2028) under the Biological Sciences program (CFDA 47.074). This award funds fundamental research investigating the molecular mechanisms by which plants utilize biomolecular condensates to sense environmental stimuli and reprogram their epigenomes in response to...
- Federal Grant Award Summary Purdue University received an $800,000 Project Grant from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), awarded July 1, 2025, with completion scheduled for June 30, 2028. The grant supports the "Trilateral FPP 2023: Future Proofing Plants Through Enhancement of Yield Stability in Water-Limited Environments" project, which aims to identify genetic and physiological...
Project Grant Summary: Metabolite-Mediated Gene Regulation Research Purdue University received a $1.2 million Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for the period June 1, 2026, through May 31, 2029. This research initiative will produce fundamental scientific knowledge and methodologies advancing understanding of how plant cells regulate gene expression through metabolite-mediated mechanisms. Using petunia flowers as a model system, the project will investigate how biosynthetic enzymes function as metabolite sensors to control chromatin-based gene regulation by modulating histone acetylation and transcription. Research deliverables include characterization of enzyme-metabolite interactions, mapping of spatiotemporal dynamics of chromatin modifiers, and experimental validation of metabolite-sensing mechanisms in nuclear and cytoplasmic compartments. The project will generate broader scientific and practical outputs including bioinformatics tools and biophysical methodologies applicable to plant systems and other biological contexts. Training and workforce development constitute significant deliverables, encompassing postdoctoral researcher and student education across metabolism, gene regulation, bioinformatics, and biophysics disciplines. Additionally, the award supports public outreach activities focused on plant chemical diversity and has potential biotechnology applications for metabolic engineering and crop improvement through optimized production of beneficial natural products and enhanced plant health outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 4/28/26 |