Federal Project Grant Award Summary

The National Science Foundation (NSF), Division of Materials Research, awarded Virginia Polytechnic Institute & State University a $440,018 Project Grant (CFDA 47.049, Mathematical and Physical Sciences) effective July 1, 2026, through June 30, 2031, to develop genetically programmable protein nanofibers for mechanically tunable engineered living materials (ELMs). The research employs rational design and artificial intelligence methodologies to enable bacterial cells to produce specific protein building blocks that self-assemble into nanofiber networks with predetermined mechanical properties. These networks will be utilized to fabricate bioplastics and gels, with applications across biotechnology sectors. The project delivers both fundamental scientific knowledge—specifically, a predictive roadmap for correlating protein modifications to their assembly into larger structures with desired material properties—and applied research outputs in the form of novel, sustainably produced biological materials that combine the mechanical performance of synthetic materials with the self-repair and adaptive capabilities of natural living systems.

Beyond core research deliverables, the award includes significant educational and outreach components designed to advance STEM workforce development. Virginia Tech will establish a virtual mentoring network connecting K-12 students in rural regions to active research programs, creating career pathway exposure to biotechnology and materials science. Additionally, the project funds public-facing content development through accessible blogs and podcasts that communicate engineered living materials science to general audiences and demonstrate the sustainability benefits of biological technology approaches. These educational and communication activities support NSF's mission to strengthen the Nation's scientific enterprise while cultivating the next generation of skilled professionals in biology, materials science, and engineering disciplines.