Project Grant 2533124
- The National Science Foundation (NSF) awarded a $500,000 Project Grant under the Engineering program (CFDA 47.041) to the South Dakota School of Mines & Technology. The primary objective of this 2-year award is to develop a cell-free method for producing biodegradable polyhydroxyalkanoate (PHA) polymers from agricultural feedstocks. Key anticipated research activities include: 1) engineering a microbial strain to synthesize PHA precursors from corn stover, 2) using thermostable enzymes...
- The National Science Foundation awarded a $716,898 Project Grant to the University of North Texas under the Biological Sciences federal grant program (CFDA 47.074) to develop advanced biocatalyst tools and resources to enable biogas-based biomanufacturing from August 15, 2022 to July 31, 2025. Specifically, the University of North Texas will utilize genetic engineering and metabolic modeling to advance methanotroph-based biotechnologies for the sequestration and utilization of methane and carbon...
- This Project Grant award of $575,765 from the National Science Foundation's (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 Engineering) supports research to enhance the production of biochemicals from sustainable single-carbon (C1) feedstocks using bacteria. The key objectives are to understand the regulation of carbon metabolism in anaerobic acetogenic bacteria and use this knowledge to engineer them as effective producers of valuable fuels and...
- This Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $2,572,498 to develop new bioplastics with diverse properties. The project aims to computationally design complex enzymes within engineered bacteria to produce novel, sturdy bioplastics that can withstand high temperatures and be easily recycled or biodegraded. The award will fund interdisciplinary research to engineer polyketide synthases (PKSs)...
- The U.S. National Science Foundation (NSF) awarded a $537,639 Project Grant under the Engineering program (CFDA 47.041) to the University of Utah to develop new biodegradable bioplastics derived from polyhydroxyalkanoates (PHAs) as a sustainable alternative to traditional plastics. The project will chemically modify PHA-based plastics to enhance their functionality and biodegradability, and evaluate their environmental impact, including the potential to reduce microplastic pollution and mitigate...
- This $195,000 Federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research by the University of Colorado to accelerate the development of sustainable bioplastics. The key objectives are to use high-throughput data capture, multiscale modeling, and machine learning to better understand the molecular and chemical mechanisms controlling the transformation of biomatter into thermoformable bioplastics. This knowledge will enable...
- This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...
- This Project Grant award for $1,000,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a polyketide-based platform to produce a range of non-canonical amino acids (NCAAs) and demonstrate their incorporation into proteins expressed by the bacterium Bacillus subtilis. The key objectives of the 3-year project are to: 1) engineer a polyketide synthase (PKS) system to produce threonine and evolve it for increased productivity; 2) utilize...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $463,136 Project Grant to the University of Massachusetts Lowell to explore a hybrid approach to upcycling waste polyethylene (PE) into value-added chemicals. The two-step process involves oxidative catalytic pyrolysis to decompose PE into intermediate products, followed by bioconversion using engineered yeast to produce nylon precursors and other platform chemicals. The research aims to develop an economical...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
This Project Grant award of $458,552.00 from the National Science Foundation's Engineering program (CFDA 47.041) supports research to significantly reduce the downstream processing costs associated with producing methane-derived polyhydroxyalkanoate (PHA) biopolymers. The project aims to genetically engineer methane-consuming bacteria to facilitate easier recovery of the PHA polymers, with the goal of a 5-10% reduction in capital expenditures and up to 15% in operational expenditures. Key objectives include engineering the bacteria to automatically break open after PHA production and reduce protein output to simplify purification. This research will yield robust genetic engineering tools and strains, as well as advance fundamental scientific understanding in synthetic biology, metabolic engineering, and biomanufacturing. The project, led by the University of California, Davis, will also include educational and workforce development programs to prepare students for careers in the biomanufacturing industry.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.6k | 8/18/25 |