Project Grant 2532136
- This $440,262 federal Project Grant award was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) grant program. The award supports a collaborative research project between professors at the Georgia Institute of Technology and Utah State University to study the evolution of archaeal protein tyrosine phosphatases (PTPs), a family of enzymes crucial for cellular signaling processes. The research aims to quantitatively...
- This federal Project Grant award of $431,392, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research on the conformational dynamics and evolution of archaeal protein tyrosine phosphatases (PTPs). The principal investigators from Georgia Institute of Technology and Utah State University will use advanced biomolecular simulations, X-ray crystallography, enzyme kinetics, and NMR spectroscopy to quantitatively...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $778,507 to Wayne State University to develop novel chemical tools to study how the addition of phosphate groups to histidine amino acids in proteins affects their biological functions in mammalian cells. The principal investigator, Dr. Mary Kay Pflum, is utilizing kinase-catalyzed labeling with ATP analogs to investigate histidine phosphorylation, which is less...
- This Project Grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $1,445,996 to the University of Utah from July 1, 2022 to June 30, 2025. The funding supports research by Drs. Eric Schmidt and Chris Hill to characterize the structure and function of novel polyketide synthases found in mammalian biology, including human biology. The researchers will use biochemical methods like kinetic analysis and...
- This Project Grant from the National Science Foundation's Mathematical and Physical Sciences Directorate provides $500,000 to Eastern Illinois University to develop peroxisome targeting chemical technologies and tools. Under the award, Professor Beck and his students will adapt peroxisome targeting peptide sequences to create modular moieties that can direct small molecule cargoes to peroxisomes. They intend to characterize these peroxisome interaction moieties to assess cell permeability,...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- The National Science Foundation Division of Chemistry awarded a $537,452 Project Grant to the University of Arizona under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new light-promoted chemical reactions for studying the biological role of the mitochondrial translocator protein tryptophan-rich sensory protein (TSPO). Over a three-year period from November 1, 2022 to December 31, 2025, Dr. Michael Taylor will design photoactivatable probes and conjugation reactions...
- Colorado State University Sponsored Programs Division was awarded a three-year $406,500 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program to develop chemical tools to investigate phosphatidylinositol mannosides (PIMs) in the Corynebacterineae suborder of bacteria. Under the award beginning July 1, 2023, Professors Benjamin Swarts of Central Michigan University and Mary Jackson of Colorado State University will synthesize carbohydrate-based probes...
- This $574,915 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Monika Raj of Emory University to develop new chemical probes and strategies for detecting and studying modifications to the amino acid histidine in proteins. The goal is to create novel chemical probes capable of selectively labeling modified histidine residues in proteins and capturing the...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professors Amy Barrios and Brian Popp from the University of Utah and West Virginia University, respectively, in developing a "Chemical Toolkit for Monitoring and Modulating Receptor Tyrosine Phosphatase Activity." The $639,000 award, running from September 1, 2025 to August 31, 2028, aims to create chemical tools to study phosphatase enzymes involved in cellular signaling pathways. The investigators will develop fluorogenic substrates and targeted inhibitors to monitor the activity of specific phosphatases, identify signaling molecules that regulate them, and validate inhibitors that can block their function. This work will provide new biological insights into the roles of these critical enzymes in cellular communication processes, with a focus on phosphatases involved in neurological development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $639.0k | 8/22/25 |