Project Grant 2530093
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
- This $328,416 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports a collaborative research program to investigate the role of aging and type-2 diabetes on the microstructural changes and fracture behavior of bone. The research aims to reveal how advanced glycation end-product cross-links in the collagen network impact bone resistance to fracture under both physiological and fall loading conditions. Using human tibia and fibula specimens from...
- This $113,932 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) aims to develop a novel magnetically responsive biomaterial that can replicate the microstructures and physical stimuli of natural human bones. The principal investigator at Boise State University will 3D print this biomaterial into porous scaffolds that can promote the growth and differentiation of mesenchymal stem cells into bone-forming cells. The biomaterial...
- This Project Grant award of $270,189 from the National Science Foundation's Engineering program (CFDA 47.041) supports a collaborative research program at Virginia Polytechnic Institute & State University to investigate the role of aging and type-2 diabetes on bone fracture behavior. The research aims to study how changes to the collagen network in bone, caused by aging and diabetes, affect the material properties and fracture resistance of bone under both physiological and fall-event...
- This Project Grant award from the National Science Foundation (NSF) Division of Materials Research, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $322,382 to the University of Connecticut Health Center (UCHC) from September 1, 2023 through August 31, 2026. The goals of this collaborative research project are to use computer modeling and high-energy synchrotron X-ray diffraction experiments to better understand how the incorporation of cobalt (Co) and chromium...
- The National Science Foundation awarded a $280,774 Project Grant to the University of Colorado Denver under the Engineering program (CFDA 47.041) for research determining the impacts of lacunar-canalicular remodeling on bone fracture toughness. The three-year award beginning September 15, 2021 will fund collaborative research between the University of Colorado Denver's Department of Mechanical Engineering and the Regents of the University of Colorado to analyze how changes to the...
- This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
- This $430,152 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund the development of a stand-alone simulation platform for designing 3D-printed tissue engineering scaffolds to serve as bone graft substitutes. The platform will combine finite-element modeling, statistical design software, and specialized composite...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $601,120 to the University of Delaware to conduct a translational validation study of next-generation methods for diagnosing and predicting bone fracture healing. The study will utilize ultrashort echo time magnetic resonance (UTE-MRI) imaging and finite element-based virtual...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Montana State University a $413,072 Project Grant under the Engineering (CFDA 47.041) federal grant program. The grant will fund collaborative research to determine the impacts of lacunar-canalicular remodeling on bone fracture toughness. Montana State University will lead the research as the awardee, working with partners to examine bone microstructure changes at the cellular level and their...
This $420,000 federal Project Grant award was provided by the National Science Foundation (NSF) through its Office of International Science and Engineering (OISE) program (CFDA 47.079) to Lehigh University, a private research university located in Fountain Hill, Pennsylvania. The goal of this 4-year project is to develop advanced computational models and simulations to predict bone healing outcomes for people with fractures that heal poorly. The research will involve creating digital twins of real bones using medical imaging data, and then using finite element modeling and probabilistic methods to simulate the bone remodeling and healing process over time. This will help doctors and patients make more informed decisions about treatment options when bone healing is delayed or fails to occur. A key part of the project is also providing a research exchange opportunity for a mechanical engineering graduate student to collaborate with the AO Research Institute in Switzerland, a global leader in biomechanics and bone fracture care.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.0k | 8/27/25 |