Project Grant 2529875
- The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
- This $472,597 National Science Foundation project grant supports research on the photophysiology and bio-optics of mesophotic coral reef ecosystems in the Red Sea. Funded under the Biological Sciences program (CFDA 47.074), the research will employ an interdisciplinary approach including fieldwork, laboratory analysis, and advanced imaging to establish the light-harvesting properties of corals thriving at depths with extremely limited light availability. Specifically, the team will collect and...
- The U.S. National Science Foundation (NSF) awarded a $426,000 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to The Regents of the University of California, San Francisco (UCSF) to conduct collaborative research on developing novel protein-based materials for photosynthetic energy transduction. The multi-year project, led by Professors Michael Therien and David Beratan of Duke University and William DeGrado of UCSF, aims to design and construct protein-based...
- This $493,073 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports collaborative research at the University of California, Santa Barbara (UCSB) on the evolutionary processes that enable a genus of ciliates known as Mesodinium to acquire and maintain phototrophy through organelle sequestration. The 3-year project will use comparative cellular, metabolic, and genetic analyses to understand the adaptations that allow some Mesodinium species to...
- The National Science Foundation (NSF) awarded a $437,749 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of North Carolina at Charlotte. The grant supports a research project to investigate a new class of luminescent protein materials and their potential applications in imaging, sensing, and biological tracking. The project aims to characterize the chemical and physical properties of known luminescent protein-metal compounds, and leverage...
- The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
- The National Science Foundation awarded a $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to identify a novel green fluorescent small molecule in the heterotrophic dinoflagellate Gyrodinium jinhaense AP17. The two-year award running from January 2023 to December 2024 will support postdoctoral research fellowship activities at Konstanz, Germany. The fellowship aims to determine the fluorescent molecule's structure, identify the underlying chemical and...
- This $476,910 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program (CFDA 47.074) supports research examining light signaling in marine photosynthetic organisms. Specifically, the grantee Southern Methodist University will investigate the function of blue light sensing proteins called aureochromes that are widely distributed in marine algae. The university will study the photochemical kinetics, expression patterns, and...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $373,168 supports collaborative research between the University of Wisconsin-Milwaukee and Northeastern Illinois University to understand the molecular mechanisms behind how myxobacteria use phytochromes to sense light and convert that signal into developmental changes, such as fruiting body formation. The research will utilize cutting-edge techniques including time-resolved X-ray...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $665,885 to the Woods Hole Oceanographic Institution (WHOI) to conduct collaborative research on the evolution of acquired phototrophy in Mesodinium ciliates. The key products and services to be delivered under this 3-year award, which began on March 1, 2024, include: Comparative studies of the cellular, metabolic, and genetic adaptations across a genus of Mesodinium ciliates that...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $579,398 to Yeshiva University in New York, NY to characterize and engineer novel calcium-regulated photoproteins discovered in bioluminescent marine organisms known as siphonophores. The research aims to expand the repertoire of known photoproteins, which have broad applicability for studying intracellular calcium dynamics. The project will provide hands-on training for undergraduate students, yielding peer-reviewed publications, conference presentations, and field research experience. Key elements will also be integrated into the university's biochemistry and biophysics curriculum. The research activities include using techniques such as liquid chromatography-mass spectrometry, RNA sequencing, and X-ray crystallography to assess the functional properties of this novel photoprotein group across siphonophore species. The project also seeks to engineer enhanced photoproteins through mutagenesis and computational modeling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $579.4k | 7/29/25 |