Project Grant 2529800
- This three-year, $455,159 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research into the self-assembly of collagen-like octadecamers based on the stem region of C1q and related defense collagens. Principal Investigator Jeffrey Hartgerink at William Marsh Rice University will study the hierarchical assembly of collagen mimetic peptides derived from collagen's branch and stem regions using solid phase peptide synthesis,...
- The National Science Foundation (NSF) awarded a $600,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Dr. Jeffrey D. Hartgerink of Rice University. The grant supports research to reveal the atomic structure of collagen, the most abundant protein in the human body, and investigate the circumstances under which a novel collagen superstructure shape is formed. This research aims to advance the understanding of collagen's role in biological behavior,...
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
- This Project Grant award for $140,390 was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports research to develop porous peptide frameworks inspired by the modular architecture of proteins. The research aims to engineer these frameworks by appending peptides with aromatic π-stackers to guide the predictable self-assembly of the peptides into sophisticated porous materials. If successful, these...
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- The National Science Foundation Division of Materials Research awarded Tufts University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to support research titled "DYNAMIC PROTEIN-BASED BIOMATERIAL DESIGNS FOR BIONIC COATINGS" from June 15, 2021 through May 31, 2024. The grant funds research into developing dynamic protein-based biomaterial designs that can be used for bionic coatings. The Mathematical and Physical Sciences program aims to...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $300,000 to New York University (NYU) to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing fluorinated coiled-coil hydrogels that change with temperature, and 3) assessing the potential of these materials as...
- Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
- This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
This federal Project Grant award of $800,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to Tufts University supports research led by Dr. Joshua Kritzer and co-investigators Dr. James Baleja and Dr. Yu-Shan Lin. The project aims to develop a new method for stabilizing synthetic collagen-like peptides using chemical "staples" in order to better understand the structure and function of natural collagen, the most abundant protein in the human body. The researchers will use these stabilized collagen-mimetic peptides to map the binding sites of proteins that interact with collagen and elucidate associated cellular signaling processes. The project also includes the development of professional development workshops for graduate students. The award period runs from Sep 1, 2025 to Aug 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $800.0k | 8/27/25 |