Project Grant 2528385
- This National Science Foundation Project Grant of $180,493 will support the development of an ultrasensitive point-of-care diagnostic system using clustered regularly interspaced short palindromic repeats (CRISPR) technology for early disease detection without pre-amplification of viral genomes. Funded under the NSF's Office of Integrative Activities program (CFDA 47.083), which enhances STEM competitiveness through capacity building and broadening participation, this 24-month project will...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Quarksen LLC provides funding to develop an affordable, point-of-care diagnostic device for detecting viral and non-viral sexually transmitted infections (STIs) such as chlamydia, gonorrhea, syphilis, HIV, hepatitis C, and trichomoniasis. The project aims to create a device with an array of sensors that can rapidly and accurately detect STI biomarkers from cervical...
- The National Science Foundation (NSF) awarded a $274,362 SBIR Phase I Project Grant to RT Microdx Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The grant funds the development of a novel molecular diagnostic platform for detecting respiratory diseases, including strep throat, that can be used at home without an expensive tabletop device. The platform leverages a combination of isothermal amplification and pH-sensitive polymers to detect specific bacterial DNA...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award supports the development of a novel device that can rapidly and automatically extract pathogen DNA from whole blood samples to enable faster diagnosis of sepsis. The $274,858 award to New England Hemolytics, Inc., with a project period from September 1, 2024 to February 28, 2025, will fund the testing and optimization of this technology across common sepsis-causing pathogens. The...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $331,189 to the University of Central Florida Board of Trustees aims to develop an affordable, portable platform for virus detection. The project integrates protein engineering and electrochemical biosensor technologies to create a stable, room-temperature enzyme-based system for isothermal amplification and detection of viral fragments. This innovative approach addresses the need...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- The National Science Foundation (NSF) awarded a $274,438 SBIR Phase I grant to Script Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project, titled "CASPLUS: A Safer, More Efficient, and Targeted Method of Deploying CRISPR In Vivo," aims to develop a platform technology that significantly reduces the potential inaccuracy of current gene editing techniques. The innovation targets the desired gene, increasing the safety and efficacy of...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project aims to advance infectious disease research and diagnostics through improved genetic sequencing. The $304,995 award, granted on June 1, 2025, will fund the development of the Host-Pathogen Enrichment Platform (HOSTPATHEP), which will produce infection-specific reagent products to enhance the sensitivity and specificity of RNA sequencing assays in...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Teardx, LLC will fund the development of a rapid, point-of-care diagnostic test to accurately detect ocular herpes simplex virus (HSV-1) infections. The project aims to create a user-friendly, minimally invasive sampling tool and assay that can be used by eye specialists and urgent care clinicians to quickly screen for active HSV-1 infections, which are a leading cause...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Macula Vision Systems Inc., a for-profit organization, supports the development of a novel microscopy platform to automate the interpretation of microbiology lab tests performed in hospitals. The project aims to address the shortage of trained lab technicians by engineering a specialized light source, customized camera, and AI-enabled algorithms to analyze...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant of $305,000 awarded to Cleaved Diagnostic Corporation on October 1, 2025 aims to develop a novel CRISPR-Cas12a-based molecular diagnostic platform for the rapid and cost-effective detection of congenital cytomegalovirus (CCMV) from newborn dried blood spots. The key product deliverables include a one-step CCMV screening assay that addresses limitations of current PCR-based diagnostics, such as low sensitivity, long turnaround times, and off-site processing requirements. By providing a scalable, sensitive, and clinically implementable CCMV detection solution, this project seeks to enable universal newborn screening and early intervention to reduce the significant long-term health impacts and costs associated with this condition, which affects approximately 25,000 U.S. babies annually. Future extensions of the platform are also planned to detect additional infectious disease pathogens, broadening its public health impact.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $305.0k | 7/30/25 |