Project Grant 2527337
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
- This federal Project Grant award of $339,999, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research to study the spatiotemporal dynamics of intercellular signaling in engineered multicellular bacterial systems. The research aims to develop novel mathematical modeling techniques that can better predict the behavior of spatially extended synthetic bacterial populations, which have potential applications...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This $160,000 federal Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research on the spatiotemporal dynamics of intercellular signaling in growing bacterial populations. The research aims to develop mathematical modeling techniques to better understand and predict the behavior of engineered multicellular bacterial systems, which have potential applications in areas like gut microbiome...
- This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
- This $100,000 Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop new theory and predictive models for understanding how environmental pressures shape the evolution of virulence in opportunistic bacterial pathogens. The project aims to: (I) Develop and test predictive models of strain-specific virulence, transmission, and environmental origins for the model pathogen Pseudomonas aeruginosa; and (II)...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports a research project at Bryn Mawr College focused on understanding the molecular mechanisms of phospholipid trafficking in bacterial cell membranes. The $368,978 award, with a performance period from August 15, 2025 to July 31, 2028, will engage student-scientists in interdisciplinary research at the interface of biochemistry, biology, and molecular biophysics. The project...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $461,575 to Earlham College supports research to investigate how a bacterial enzyme, ProXP-X, recognizes and binds to both L- and D-amino acids, which is critical for protecting bacterial cells from the toxicity of D-amino acids. The project aims to characterize the mechanisms by which ProXP-X identifies and binds its targets, and determine if its activity prevents D-amino acid toxicity in living...
- This $309,797 Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) will support a two-pronged research effort to study the emergence of long-range coherence in motile microorganismal systems with quenched disorder. The first component involves experimental studies of bacteria, amoeba, and bladder cancer cells in disordered environments to understand how self-propelled motion leads to large-scale collective behavior. The...
- This federal Project Grant award of $1,000,000.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) was provided to The Trustees of Princeton University to study "Quorum Sensing Across Scales and Between Domains". The project aims to investigate bacterial communication processes, known as quorum sensing, to better understand how bacteria can synchronize behavior and potentially control harmful pathogens or promote beneficial bacteria. Key objectives...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $517,732 to Trustees of Dartmouth College to conduct research on data-driven prediction of phenotypic heterogeneity in bacterial systems under antibiotic stress. The research focuses on understanding how bacteria, specifically E. coli, respond to antibiotics and investigate non-genetic differences such as variations in individual cell growth rates that emerge under these conditions. The project combines cutting-edge single-cell experiments with mathematical modeling to predict non-genetic differences in growth and biochemical composition, with the goal of deepening the understanding of antibiotic resistance and microbial physiology. The award runs from September 15, 2025 to August 31, 2028 and provides rich opportunities for undergraduate and graduate student training in quantitative biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $517.7k | 8/5/25 |