Project Grant 2526696

Award Date 6/15/25
Completion Date 12/31/28
Dollars Obligated $527K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Knoxville, TN 37996, USA
Similar Awards
This Project Grant award, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), will support Professor Trevor Hayton of the University of California, Santa Barbara (UCSB) in the development of triphenylmethyl (trityl) group-based small molecule delivery agents, magnetic materials, and metal nanoclusters. The $580,406 award over 3 years (9/1/2024 - 8/31/2027) will enable Professor Hayton to explore new synthetic methodologies,...
Under a $595,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program, Professor Thomas Lectka of Johns Hopkins University will pursue two complementary strategies to selectively modify specific carbon-hydrogen or carbon-carbon bonds within complex molecular structures. The first approach will utilize hydrogen bonding to direct site-selective functionalization reactions, while the second will leverage metal ion binding to deactivate...
This $399,935 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Professor Kyriakos C. Stylianou and his team at Oregon State University. The research aims to develop a deeper understanding of the fundamental mechanisms underlying metal-organic framework (MOF)-based photocatalysis, with a focus on investigating hydrogen-deuterium isotope exchange reactions. The project will use in-situ...
This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, supports an integrated university-industry research program to develop new methods for hydrogen isotope labeling of pharmaceuticals. The $329,206 award, with a period of performance from March 1, 2025 to February 28, 2027, will enable researchers from Wayne State University and Merck & Co. to pursue two key objectives: (1) developing heterogeneous photocatalysts...
This $374,593 National Science Foundation award under the Mathematical and Physical Sciences program (CFDA 47.049) will support the development of new cobalt-based compounds to catalyze reactions involving parahydrogen-induced polarization at Texas A&M University from April 1, 2023 to November 30, 2024. Specifically, the awardee will synthesize diamagnetic cobalt complexes serving as PHIP catalysts across a range of substrates, including olefins, alkynes, and arenes. These complexes will...
This Project Grant award, valued at $550,692.00 and provided by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports a research team at the University of Illinois at Chicago in developing new chemical reactions using N-alkenylnitrones and N,O-dialkenylhydroxylamines as reactive intermediates. The goal is to rapidly assemble novel molecules with defined three-dimensional structures through...
The National Science Foundation Division of Chemistry awarded a $537,452 Project Grant to the University of Arizona under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new light-promoted chemical reactions for studying the biological role of the mitochondrial translocator protein tryptophan-rich sensory protein (TSPO). Over a three-year period from November 1, 2022 to December 31, 2025, Dr. Michael Taylor will design photoactivatable probes and conjugation reactions...
This $575,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will fund research at the University of California, San Diego to synthesize and study the reactivity of unusual main group elements stabilized by transition metal isocyanide complexes, from July 1, 2023 to June 30, 2026. Specifically, Professor Joshua S. Figueroa will manipulate boron monofluoride and diphosphorus molecules, which are...
This Project Grant award, valued at $643,347.00, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The principal investigator, Tibor Szilvási of the University of Alabama-Tuscaloosa, is focusing on developing computational tools to empower the design of efficient molecular catalysts. The research aims to use high-performance computational screening to identify optimal catalyst structures, compositions, and...
The National Science Foundation (NSF) Division of Chemistry awarded a $299,978 Project Grant to Washington State University (WSU) through the Mathematical and Physical Sciences program (CFDA 47.049). The funding aims to develop an innovative approach to create unique mixed-metal structures in metal-organic frameworks (MOFs) through nuclear transmutation and assess their stability under neutron irradiation. The research project seeks to apply nuclear transmutation within MOFs to introduce...

This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the research of Dr. Joseph Clark at Marquette University. The total funding amount is $526,747, awarded on June 15, 2025 with a completion date of December 31, 2028.

The funded research focuses on developing copper-catalyzed reactions to selectively incorporate tritium (a radioactive isotope of hydrogen) into small organic molecules. This will enable the production of tritium-labeled compounds for use as research tools, such as in radioligand binding assays and absorption/metabolism studies of drug candidates. Additionally, the project aims to establish molecular rotational resonance spectroscopy as a new analytical technique to characterize and quantify the enantiomeric excess of these tritium-labeled enantiomeric compounds. The broader impacts include providing STEM career development and training for undergraduate students, with a focus on engaging underrepresented groups. No sub-awards are planned for this award.

Generated 7/1/25, 1:53 AM