Project Grant 2516905
- This $241,401 Project Grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, supports the development of in vitro models to better understand the mechanisms driving chronic pain and identify new treatment targets. Specifically, the award will fund the engineering of a physiologically-relevant multi-compartment model of nociceptor hypersensitivity and the establishment of a neuroimmune-specific model to test anti-inflammatory macrophage mechanisms...
- This $200,000 federal Project Grant was awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to the Stevens Institute of Technology to conduct fundamental research on the development of soft robotic devices for musculoskeletal manipulation to provide targeted pain relief. The research aims to produce highly constrained, customized soft robotic devices that can safely perform physical therapy to address various pain conditions, from back pain to arthritis to...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research by Function Therapeutics Inc. to investigate the use of a new class of small molecule compounds called Parmodulins for the treatment of neuropathic pain. The $499,863 award, granted on September 11, 2025, will fund research to synthesize and test various Parmodulins for their ability to modulate the...
- This $591,122 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research by the Massachusetts Institute of Technology (MIT) to decode and modulate the emotional aspect of pain. Key objectives include: Systematically characterizing autonomic responses to identify signatures for different mouse pain models. Performing in vivo imaging and...
- This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
- This federal Project Grant award for $667,349.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award is supporting research conducted by the University of Pennsylvania to investigate the role of endogenous opioid signaling and neural circuits involved in modulating pain perception and placebo analgesia. The research aims to elucidate the...
- This $4,039,366 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), will support a research project titled "A Fully Humanized Functional Genomic Screen to Identify and Validate Pain Therapeutic Targets" under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279). The project will leverage innovative CRISPR-based screening and human dorsal root ganglion (DRG) transcriptomic data to...
- This $2,370,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop advanced human pluripotent stem cell (HPSC) tools to create comprehensive, region-specific models for studying pain circuitry. The award to Trustees of Tufts College (Tufts University) supports three main objectives: 1) Developing scalable methods to generate region-specific sensory neurons and...
- Just Health Care LLC received a $256,000 Project Grant award from the National Science Foundation Division of Industrial Innovation on March 1, 2021 to complete work by August 31, 2021. The grant was provided under the NSF Engineering program (CFDA 47.041) to support the company's SBIR Phase I project titled "Measuring and Mapping Pain Intensity onto a 3D Image of the Human Body." The goal of the project is to develop a new method for quantifying pain levels and visualizing pain...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
This Project Grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is for the development of a system for automated pain behavior testing across preclinical disease models in rodents. The project aims to assess the commercial feasibility of this new behavior testing and analysis system for use in preclinical pain research. The total funding amount for this award is $305,000.00, with a start date of January 15, 2026 and an ultimate completion date of December 31, 2026. The awardee is Tactorum Inc., a small business located in New York, NY. The broader/commercial impact of this project includes reducing resources needed for pain behavior studies, decreasing the time and training required for experiment completion, and generating cleaner data to improve the translational viability of preclinical pain research. By year 3 of production post-award, the project is expected to generate $1.85 million in revenue from hardware and software products.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $305.0k | 8/20/25 |