This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $241,401 to Arizona State University to engineer physiologically relevant in vitro models of nociceptor hypersensitivity, a key feature of chronic pain. The objectives are to (1) develop a multi-compartment model to study nociceptor hypersensitivity and validate its response to noxious stimuli, and (2) establish a neuroimmune-specific model to test anti-inflammatory macrophage mechanisms of pain resolution. The project aims to enhance understanding of the mechanisms driving chronic pain and improve the translational efficacy of pain treatments. No subawards are planned under this award, which has an ultimate completion date of November 30, 2025.
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