This $448,818 Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) aims to develop a miniaturized, sensitive, and user-friendly electromagnetic (EM) sensing platform for rapid bacterial diagnostics. The project leverages integrated circuit (IC) chips and microfluidic integration to create a portable system capable of distinguishing bacterial phenotypes and detecting strain-specific surface biomarkers. Key innovations include: 1)...
This National Science Foundation (NSF) Project Grant award under CFDA Program 47.041 - Engineering, in the amount of $232,786, will support collaborative research on robophysical modeling of bacterial swimming motion. The project aims to advance the understanding of how fluid mechanical forces shape the ways bacteria navigate their complex environments and interact with each other. By adopting techniques of robophysical modeling, the researchers will isolate physical effects governing...
This $449,996 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a highly sensitive, low-cost sensor platform to detect circulating tumor DNA (ctDNA) - a key biomarker for early cancer diagnosis, particularly in non-small cell lung cancer. Researchers at the University of Minnesota, in collaboration with the University of Cambridge, are combining microwave photonics and polymer-based micro-ring resonator technology to create...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $441,868 Project Grant to the University of Houston System (UH) to investigate bacterial persistence and antibiotic tolerance, a critical global public health challenge. The primary research objectives are to: (1) utilize high-throughput screening and genomic sequencing to identify genes important for bacterial persistence, (2) validate potential persistence-mediating mechanisms, and (3) conduct genetic studies...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
The National Science Foundation (NSF) awarded a $125,731 Project Grant to the Kennesaw State University Research And Service Foundation, Inc. (KSU R&SF) on October 1, 2023. The award is funded through the NSF's Engineering program (CFDA 47.041), which supports a wide range of research and development activities to advance engineering knowledge and capabilities. This particular award will tackle the challenge of exploring, analyzing, and interpreting the complex interactions in the tumor...
This $265,007 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support collaborative research to advance the understanding of bacterial swimming motion. The research aims to leverage robophysical modeling techniques from robotics to realistically emulate and study the complex interplay of physical and biological factors governing bacterial motility behaviors. Key objectives include elucidating how fluid mechanical forces shape the ways...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) project grant of $575,000 awarded to the New Jersey Institute of Technology (NJIT) aims to study how the microstructure and interstitial fluid pressure within a biomimetic tumor-on-a-chip model can impact the invasive behavior of cancer cells. The research will utilize light-assisted bioprinting and microfluidics to construct and characterize a tunable 3D solid tumor microtissue model, examining how parameters like matrix...
This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...