This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,990 to Scorpido Photonics aims to develop a novel optical method for rapid and accurate point-of-care cancer diagnosis through the use of plasmonic nanobubbles. The project seeks to integrate this plasmonic nanobubble sensor technology into a standard endoscope to enable minimally invasive, non-invasive detection of microscopic tumors during lung cancer diagnostic procedures....
This $1,200,000 Project Grant award from the National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) aims to develop innovative diagnostic sensing technologies that can enable more frequent and comprehensive health monitoring. The key products and services to be delivered under this award include: Integrating DNA nanotechnology and CMOS electronics to create highly sensitive and easy-to-use biosensing platforms that can detect a wider range...
This National Science Foundation (NSF) CAREER grant, awarded under the Engineering program (CFDA 47.041), provides $242,687 to the University of Massachusetts (UMass) to develop an ultrasensitive nanopore biosensor technology for point-of-care detection of infectious disease biomarkers. The project aims to create a next-generation nanopore sensor with unprecedented sensitivity, robustness, and reproducibility to enable rapid, accurate, and multiplexed quantification of circulating proteomics...
The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
The National Science Foundation (NSF) awarded a $650,000 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to the University of Illinois for the development of a bioinspired multispectral imaging sensor to support real-time intraoperative detection of cancer. The award aims to create a novel sensor that integrates perovskite nanocrystals and optical metasurfaces to simultaneously detect endogenous cancer biomarkers in the UV spectrum and exogenous markers...
This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
The National Science Foundation (NSF) awarded a $274,750 Small Business Innovation Research (SBIR) Phase I grant to Amplified Sciences Inc. on March 15, 2024 under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop a surface-enhanced Raman spectroscopy (SERS)-based diagnostic platform to detect and monitor multiple inflammatory biomarkers associated with various cancers. Key objectives include: 1) synthesizing ultrasensitive SERS-active dye...
This $449,996 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a highly sensitive, low-cost sensor platform to detect circulating tumor DNA (ctDNA), a key biomarker for early cancer diagnosis. The project, conducted in collaboration with researchers at the University of Cambridge, combines microwave photonics (MWP) and polymer-based micro-ring resonator technology to create a portable and affordable solution for point-of-care cancer screening. The sensor platform addresses limitations of current diagnostic tools by employing a microwave frequency sweep modulation approach to replace expensive tunable lasers, dramatically reducing costs while enhancing precision and scalability. The award supports validation of the sensor platform through rigorous testing against commercial ctDNA reference materials to ensure reliability and reproducibility. Beyond healthcare, the project aims to adapt the versatile sensor platform for applications in environmental monitoring, agriculture, and other fields. The award is a collaborative effort between the U.S. National Science Foundation and the U.K. Engineering and Physical Sciences Research Council, with sub-awards planned.