Project Grant 2516225
- The National Science Foundation (NSF) awarded a $919,999 Project Grant under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This 3-year grant, beginning September 1, 2023, supports research to investigate the evolution and functional role of small regulatory RNAs (sRNAs) in diverse bacterial lineages, particularly those living symbiotically within pest insect hosts. The project aims to determine how sRNA sequence divergence and...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
- The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences provides $300,000 to the University of California, San Diego for research titled "EAGER: DEVELOPING A HIGHLY SELECTIVE, ORTHOGONAL, ENZYMATIC RNA LABELING TECHNOLOGY VIA DIRECTED EVOLUTION OF AN RNA TRANSGLYCOSYLASE." The period of performance is from August 15, 2021 to July 31, 2023. The funding supports research under the NSF's Biological Sciences program (CFDA 47.074). The goal...
- The National Science Foundation's Biological Sciences Federal Grant Program (CFDA 47.074) awarded $986,944 to William Marsh Rice University to develop a self-amplifying RNA (saRNA) system for bacterial protein synthesis. The project, titled "TOOLS4CELLS: Development of Self-Amplifying RNA Systems for Bacterial Protein Synthesis," aims to engineer a versatile saRNA platform that enables precise, short-term protein production in a broad range of bacterial species without the risks of...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
- The National Science Foundation (NSF) awarded a $445,153 Project Grant to the San Diego State University Research Foundation under the Biological Sciences (CFDA 47.074) federal grant program. The grant supports research to investigate how RNA genomes of bacteriophages (viruses that infect bacteria) are packaged into their protective protein capsids. Specifically, the project will describe the RNA structures involved in selective packaging and identify key signals recognized by the coat...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
- The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
This $700,000 Project Grant was awarded by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program to the University of California, San Diego (UCSD) on August 1, 2025. The grant funds a 3-year research project to investigate how bacteria use RNA "switches" called riboswitches to regulate the import and export of metal ions, which are important for cellular function but can be toxic in excess. Specifically, the project aims to map the co-transcriptional folding pathways of manganese-sensing riboswitches in E. coli bacteria to better understand how the signal from RNA-metal ion interactions is propagated to control gene expression of metal ion transporters. The gained knowledge is expected to aid in engineering new RNA-based biosensors for detecting metal ions in water and other applications. The project will also engage and support community college students interested in transferring to UCSD and participating in the research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $700.0k | 7/23/25 |