Project Grant 2515406
- This $262,588 National Science Foundation Project Grant under the Geosciences program (CFDA 47.050) will support research into prebiotic chemistry processes relevant to the origin of life on Earth. The Foundation For Applied Molecular Evolution, Inc. will use the funding to advance scientific understanding of geological environments on Earth 4.35 billion years ago that could have facilitated the emergence of the first genetic molecules. Key deliverables include completing structural analysis...
- The National Science Foundation (NSF) awarded the University of New Mexico (UNM) a $500,000 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program. The grant supports research on the design of heterochiral DNA nanostructures for biomaterials applications. The project aims to study the structure and function of these hybrid DNA materials that combine right-handed (D-DNA) and left-handed (L-DNA) forms, and to use computational modeling and experimental...
- The National Science Foundation (NSF) awarded a $549,996 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the Scripps Research Institute to study the chemical synthesis and modification of new anti-fungal and anti-malarial medicines. The grant supports Professor Ryan Shenvi's work to develop an integrated experimental and computational workflow to identify chemical characteristics and reactions needed to adapt the naturally-occurring compound siccanin into a...
- The Salk Institute for Biological Studies was awarded a three-year, $881,161 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) beginning July 1, 2021 to conduct research on Cross-Chiral Genetic Systems. The Biological Sciences program aims to promote advancement in the biological sciences and strengthen the national scientific enterprise through increasing knowledge and understanding of major problems. As part of this grant, The Salk Institute will...
- This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
- This $248,968 Project Grant is funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) and supports research by Professor Zhongyue John Yang at Vanderbilt University. The project aims to develop high-throughput computational workflows to investigate the origins of right-handed wrapping chirality in lasso peptides - a class of knotted, interlocked molecules with potential applications in biotechnology and therapeutics. The research combines...
- The National Science Foundation awarded a 4-year, $575,000 Project Grant to Professor Babak Borhan at Michigan State University (MSU) under the Mathematical and Physical Sciences (CFDA 47.049) program. The project focuses on developing new methodologies to rapidly identify the chirality (three-dimensional shape) of organic molecules, which is critical for understanding their physical and biological characteristics. Key objectives include designing and synthesizing supramolecular sensor...
- This Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research to develop synthetic biomaterials that mimic communication and information exchange in living systems. The $641,052 award to Emory University is focused on studying how intrinsically disordered materials can self-assemble into functional "coacervate" structures that exhibit emergent properties, such as molecular...
- The National Science Foundation (NSF) Division of Chemistry awarded a $460,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Drs. Harish Vashisth from the University of New Hampshire and Esteban A Orellana Vinueza from Dartmouth College. The 3-year grant, effective September 1, 2025, supports collaborative research to study how chemical modifications to transfer RNA (tRNA) bases affect the structure, folding, and dynamics of tRNA isodecoders, which are...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
The U.S. National Science Foundation (NSF), through its Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), awarded a $602,976 project grant to Scripps Research Institute to study the emergence of homochirality in the synthesis of biological polymers. The research, led by Professor Donna G. Blackmond, aims to understand how exclusively homochiral (single-handed) biological polymers, such as proteins and nucleic acids, evolved from chiral building blocks. This work will combine experimental organic synthesis, kinetic measurements, and computational modeling to determine the specific chain length at which homochiral chains begin to dominate. The findings will shed light on the chemical processes that occurred billions of years ago during the origin of life, provide insights into the production of modern pharmaceuticals, and enhance science education by demonstrating fundamental chemistry concepts. The project is expected to run from September 1, 2025, to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $603.0k | 8/25/25 |