Project Grant 2515389
- This $1,998,582 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support the development of biotechnology to grow cellular brain organoids capable of replicating network and activity observed in the human brain. The research team at The University of Texas at San Antonio (UTSA) will integrate these brain organoids into an engineered system and program them to solve increasingly complex associative problems, evaluating how this bioengineering...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded The Johns Hopkins University a $1,999,508.00 Project Grant to advance the field of Organoid Intelligence (OI). The project seeks to incorporate reward-based learning mechanisms into lab-grown brain organoids to enable more complex and adaptive behaviors, with the goal of creating computing devices that use substantially less energy than today's AI systems. The research team will connect the brain organoids to...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $2,000,000 Project Grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a research project at Boise State University to explore how brain-like structures grown in the lab, known as brain organoids, can be trained to control muscle contractions. The goal is to harness the power of biological neural networks to create low-power, adaptable computing systems that could have applications in healthcare, robotics, and national defense. The...
- This Project Grant award of $310,000.00 was provided by the National Science Foundation's Social, Behavioral, and Economic Sciences (CFDA 47.075) program to the University of Southern California (USC) from October 1, 2025 to September 30, 2028. The goal of this project is to develop mathematical and computational frameworks to investigate how networks of neurons and non-neuronal cells self-organize to perform complex learning and decision-making. The research aims to replicate the...
- This $200,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to establish a closed-loop hybrid intelligence (HI) framework that connects biological and physical computing systems. The research project will co-design high-resolution optoelectronic neuromodulation and neuromorphic hardware to enable closed-loop interfacing with cultured neurons and organoids. The HI system will showcase the power of optogenetic-neuromorphic co-design for...
- The National Science Foundation (NSF) Office of Emerging Frontiers and Multidisciplinary Activities awarded a $1,999,968 Project Grant to the University of California, Santa Barbara (UCSB) under the NSF Engineering (CFDA 47.041) program. This grant aims to develop scalable algorithms and hardware for human-brain-scale neuromorphic systems with practical learning capabilities. The key objectives are to create hardware-friendly local learning algorithms, a framework for continual online...
- This Project Grant award from the National Science Foundation's Computer and Information Science and Engineering (CISE) program, CFDA 47.070, provides $225,000.00 to the Regents of the University of California at Riverside to conduct research on how astrocytes, a type of brain cell, contribute to neural dynamics and information processing in the brain. The project combines computational modeling and experiments to study how astrocytes modulate neuronal activity and communication, with the goal...
- This Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research to investigate how the three-dimensional organization of the human genome controls gene expression and cell identity in the brain. The $300,000 award, spanning August 2025 to July 2027, will fund the development of new AI-powered tools to reconstruct 3D chromosome structure from single-cell experiments and simulate how changes in genome structure affect...
- This $2,000,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a project at Lehigh University to explore the use of layered biological neural networks for processing dynamic visual information. The project aims to develop functional and structural networks in multilayer neuronal organoids that can mimic the visual pathway in the brain, with the goal of enabling improved object identification in video. Ethical, legal, and social...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $1,958,603.00 to the University of California, Santa Cruz (UCSC) to explore whether lab-grown human brain tissues, known as brain organoids, can perform computations similar to artificial intelligence (AI) systems. The award, titled "EFRI BEGIN OI: REINFORCEMENT LEARNING FOR SCALABLE BIOCOMPUTING," will fund the development of tools that allow these brain organoids to interact with their environment using electrical signals and chemicals, and test whether the organoids can learn from experience, respond to feedback, and solve tasks in real-time. A key component of the project is the creation of an educational platform that will allow students and the public to participate in live experiments with the brain organoids, fostering engagement with neuroscience and computational research. The project aims to establish a scalable experimental and computational framework to uncover the learning and computational potential of human brain organoids, with the goal of inspiring the next generation of biomedical scientists and engineers while ensuring responsible and transparent research progress.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/3/25 |