Project Grant 2514774
- This $574,915 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Monika Raj of Emory University to develop new chemical probes and strategies for detecting and studying modifications to the amino acid histidine in proteins. The goal is to create novel chemical probes capable of selectively labeling modified histidine residues in proteins and capturing the...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professors Amy Barrios and Brian Popp from the University of Utah and West Virginia University, respectively, in developing a "Chemical Toolkit for Monitoring and Modulating Receptor Tyrosine Phosphatase Activity." The $639,000 award, running from September 1, 2025 to August 31, 2028, aims to create chemical tools to study phosphatase enzymes...
- This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
- This federal Project Grant award of $431,392, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research on the conformational dynamics and evolution of archaeal protein tyrosine phosphatases (PTPs). The principal investigators from Georgia Institute of Technology and Utah State University will use advanced biomolecular simulations, X-ray crystallography, enzyme kinetics, and NMR spectroscopy to quantitatively...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- This $440,262 federal Project Grant award was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) grant program. The award supports a collaborative research project between professors at the Georgia Institute of Technology and Utah State University to study the evolution of archaeal protein tyrosine phosphatases (PTPs), a family of enzymes crucial for cellular signaling processes. The research aims to quantitatively...
- This Project Grant award for $329,206 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of new methods for hydrogen isotope labeling of pharmaceuticals and their precursors. Researchers at Wayne State University and Merck & Co. are exploring the use of heterogeneous photocatalysis and electrochemistry to enable improved labeling techniques. The goal is to establish better chemical methods for incorporating...
- This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein...
- This Project Grant from the National Science Foundation's Mathematical and Physical Sciences Directorate provides $500,000 to Eastern Illinois University to develop peroxisome targeting chemical technologies and tools. Under the award, Professor Beck and his students will adapt peroxisome targeting peptide sequences to create modular moieties that can direct small molecule cargoes to peroxisomes. They intend to characterize these peroxisome interaction moieties to assess cell permeability,...
- The University of Pittsburgh received a $537,317 Project Grant award from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant supports the development of activity-based probes for genome-modifying enzymes through an interdisciplinary research project led by Dr. Kabirul Islam. The project aims to uncover novel DNA-modifying enzymes that protect and control genetic information through organic chemistry,...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $778,507 to Wayne State University to develop novel chemical tools to study how the addition of phosphate groups to histidine amino acids in proteins affects their biological functions in mammalian cells. The principal investigator, Dr. Mary Kay Pflum, is utilizing kinase-catalyzed labeling with ATP analogs to investigate histidine phosphorylation, which is less well understood compared to more commonly studied phosphorylation of serine, threonine, and tyrosine. This research aims to generate critical evidence demonstrating how histidine phosphorylation influences biological events in mammalian systems, with potential implications for understanding normal and disease-related cellular processes involving kinase enzymes. The award also includes an educational component to expose middle and high school students to protein structure and function through hands-on outreach activities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $778.5k | 8/15/25 |