Project Grant 2514128
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support the development of a novel method for modifying cellular signaling pathways using implanted electronic devices. The $10,000.00 award to the Regents of the University of California, San Francisco (UCSF) aims to create a new tool for studying complex cellular behaviors by interfacing electronic circuits with molecular networks within cells. The 2-year project, running from March...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant to the University of Chicago for the "BRING-SYNBIO: DYNAMIC COOPERATIVE BINDERS FOR ENDOGENOUSLY GATED CELLULAR CONTROL" project under the NSF Engineering program (CFDA 47.041). This project aims to develop a new class of intrinsically disordered proteins that can directly sense environmental cues and trigger rapid, targeted changes in cellular responses, such as directing tumor cells to break apart and die. The...
- This $1,200,000 Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) supports research at The Leland Stanford Junior University, also known as Stanford University, to develop quantitative models for enzyme catalysis. The project will leverage existing structural data and recent advances in X-ray crystallography to obtain ensemble information on enzyme conformational states and study how...
- This Project Grant award from the Trans-NIH Research Support program, CFDA #93.310, provides $1,350,770 to The Leland Stanford Junior University to develop a novel class of synthetic RNA-based receptors to enhance the targeting precision of mRNA-mediated adoptive cell therapies. The project aims to create a modular, programmable receptor system that can convert ligand-induced dimerization events into the expression of desired output proteins, enabling improved specificity for ablating target...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $1,400,954.00 to The Leland Stanford Junior University to conduct research on combinatorial engineering of multicellular synthetic immunotherapy systems. The research program aims to: (1) co-optimize chimeric antigen receptors (CARs) and synthetic cytokine receptors (SCRs) to enhance anti-tumor immune cell function; (2) co-engineer T cells,...
- This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $574,808 to Duke University over 5 years to study the origins of cellular heterogeneity in T-cell therapies. The research leverages cutting-edge technologies like spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered biomaterial artificial antigen-presenting cells to better understand how single-cell variability arises during the growth and modification of...
This Project Grant award, titled "BRING-SYNBIO: PROTEOLYTIC DOSAGE CONTROL OF PROTEIN CIRCUITS TO MODULATE INTERCELLULAR COMMUNICATIONS," was provided by the National Science Foundation (NSF) under the Engineering federal grant program (CFDA 47.041). The $300,000 award will support a 2-year research project at The Leland Stanford Junior University, also known as Stanford University. The objective of this project is to develop self-regulating synthetic protein circuits that can modulate intercellular communications and remove the variability associated with gene delivery methods, such as viral particle infections. The research will focus on implementing proteolysis-based incoherent feedforward loops to create dosage-controlled circuits that maintain consistent performance regardless of variations in gene delivery. This work aims to improve the reproducibility and effectiveness of emerging biotherapeutic strategies, such as CAR-T cell therapies and gene therapies, by addressing a key challenge related to variable gene expression levels in target cells.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 7/24/25 |