Project Grant 2523886
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $325,000.00 to the Massachusetts Institute of Technology (MIT) to develop 3D-integrated micro-photometer chips for monitoring neural dynamics in the brain. The project aims to elucidate the effects of beam collimation, compact chip size, and mechanical flexibility of implantable optoelectronic probes on the quality of in vivo deep-brain fluorescence recordings. The research team plans...
- This $200,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to establish a closed-loop hybrid intelligence (HI) framework that connects biological and physical computing systems. The research project will co-design high-resolution optoelectronic neuromodulation and neuromorphic hardware to enable closed-loop interfacing with cultured neurons and organoids. The HI system will showcase the power of optogenetic-neuromorphic co-design for...
- This $125,888 Project Grant was awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to Trustees of Dartmouth College to develop Photonic-Integrated-Circuit Two-Photon (PIC-2P) microscopy. The goal of this 2-year project is to create an ultra-compact, chip-scale device using optical nanostructures to overcome the depth limitations of traditional two-photon microscopy. This technology could enable faster, larger-volume tissue imaging using a minimally-invasive...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $220,000 Project Grant to The Salk Institute for Biological Studies to develop new, minimally invasive microcoaxial electro-optical probes for studying spinal neural circuits. The project aims to fabricate flexible, high-aspect ratio probes with low electrical impedance and optical losses to enable efficient activation of opsin-labeled neurons and simultaneous high-quality electrophysiological recordings in the...
- This Project Grant award of $583,679 was provided by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to the University of California, Davis (UC Davis). The grant aims to develop an innovative "Correlative, Simultaneous Microscopy of Optical Signatures (COSMOS)" system capable of simultaneously imaging multiple aspects of the brain, including fluorescence, second harmonic generation, and quantitative phase signals. This advanced microscopy system will enable...
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $630,000 to the University of Chicago to develop a new technology called the Monolithic Adjustable Photostimulation (MAP) platform for high spatiotemporal photostimulation of the nervous system. The project aims to create minimally-invasive, optically-controlled neuromodulation devices using advanced silicon heterojunctions that can precisely stimulate neural circuits, with the goal...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will support research by Trustees of Dartmouth College to develop a novel "Monolithic 3D Neuroelectronics" system. The $364,082 award, with a period of performance from September 1, 2024 to August 31, 2027, will investigate a flexible electronic design and systems research approach to establish a new 3D neural probe paradigm. The goal is to create a powerful tool for neuroscience...
- This $420,334 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) is funding a collaborative research project led by the University of California, San Diego (UC San Diego) to develop flexible, minimally invasive microcoaxial electro-optical probes for studying neural circuits in the spinal cord. The goal is to create advanced probe technologies that can precisely target and measure activity in specific spinal neural circuits, enabling better...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $174,112 project grant to Trustees of Tufts College to develop a photonic-integrated-circuit two-photon (PIC-2P) microscopy system. This system aims to enable deeper tissue imaging and faster, larger-volume cell observations compared to conventional two-photon microscopy. The project focuses on advancing nanophotonic chip technologies to overcome the depth limitations of two-photon microscopy, which is used to...
- This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...
This $325,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) to the Texas A&M Engineering Experiment Station (Tees) aims to develop 3D-integrated micro-photometer chips that enable minimally invasive, long-term stable, and high-quality fluorescence recording in deep brain regions. The research will elucidate the effects of beam collimation, compact chip size, and mechanical flexibility of implantable optoelectronic probes on the quality of in vivo deep-brain fluorescence recordings. This project seeks to overcome limitations of existing fluorescence probes, which can be bulky, rigid, and produce broad-spectrum light. The results could enhance understanding of brain functions and neurological diseases like Alzheimer's and Parkinson's. The award period is from Aug 1, 2025 to Jul 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $325.0k | 8/15/25 |