Project Grant 2512105
- This Project Grant award, valued at $332,241.00, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049). The purpose of the award is to develop a generalized Poisson-Boltzmann (PB) theory that can accommodate non-rigid biomolecular structures, enabling PB models to better handle shape changes in key biological processes such as solvation and binding. The research will be conducted by the University of Alabama and...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
- This $232,771 Project Grant, awarded on September 15, 2025, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant aims to develop computational mathematical tools to better understand protein structures and interactions, even across a wide range of mutations. This interdisciplinary research combines mathematical modeling, machine learning, and biology to analyze the complex shapes of proteins, with the goal of enabling...
- This Project Grant from the National Science Foundation's Division of Mathematical Sciences provides $244,828 to Clemson University under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research into domain decomposition methods for coupled models of non-Newtonian fluids and solid structures. Specifically, the award will fund development of parallel, accurate and efficient decoupling algorithms based on global-in-time non-overlapping domain decomposition for...
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $161,282 to Clemson University to develop novel mathematical methodologies and approximation theories for analyzing coupled fluid-structure interaction systems. The research aims to establish existence and uniqueness of solutions, ascertain qualitative solution behavior, and provide implementable numerical approximation schemes for multilayered fluid-structure...
- The National Science Foundation (NSF) awarded a $249,950 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Professor William C. Pfalzgraff and Chatham University. The funding supports the development of computational methods to accelerate the calculation of molecular properties from computer simulations, which are essential tools in modern chemistry. The project aims to create formally exact generalized master equation (GME) approaches that can efficiently...
- The National Science Foundation (NSF) awarded a $343,766 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Purdue University. The grant supports Dr. Jianing Li's research to develop data-driven, hierarchical computational modeling methods to predict the properties of biocompatible, bioactive nanomaterials for applications in sensing, drug delivery, and tissue engineering. The project aims to create systematic, adaptable approaches to coarse-grain molecular...
- This $176,321 Project Grant from the National Science Foundation Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049) will support the development of new hybrid kinetic Monte Carlo methods and algorithms for studying complex biological systems related to epidemics and biofabrication. The grant recipient, the University of South Carolina, will develop a hybrid kinetic Monte Carlo model focusing on individual mobility and heterogeneity to study...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $122,002 to the University of South Carolina to develop novel mathematical tools to analyze the long-time behaviors of coupled biology-fluid systems and transport-type equations arising in biological phenomena. The key products and services to be delivered under this 3-year award, running from August 1, 2024 to July 31, 2027, include: Exploring the delicate...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) federal grant program provides $174,976 to Clemson University from September 1, 2025 to August 31, 2028. The project aims to develop generalized Poisson-Boltzmann theory to accommodate non-rigid biomolecular structures, enabling computational models to better handle shape changes in biological processes like solvation and binding. The new computational tools will be implemented in the open-source DELPHI package and distributed to the broader biological research community. The project also provides interdisciplinary research and training opportunities for students in biophysical modeling, computation, and mathematical analysis, while engaging the public through outreach activities on how computational science contributes to human health and biomedical innovation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $175.0k | 8/7/25 |