This $869,437 project grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to investigate the fundamental mechanisms that enable polarized sorting and transport of cellular proteins within epithelial cells. The University of Florida is the prime awardee for this 3-year project, which will employ advanced microscopy, gene editing, and mass spectrometry techniques to map the molecular interactions driving directional protein trafficking. Key objectives include understanding how the clathrin sorting machinery operates in polarized epithelial cells and identifying new regulatory proteins involved in this process. The research aims to reveal principles of cellular organization essential for proper development and tissue function. The project also includes initiatives to engage high school students, undergraduates, and a postdoctoral researcher, providing them exposure to cutting-edge cell biology research and microscopy methods.
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