This Project Grant award of $360,000.00 from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a biomimetic three-dimensional engineered model incorporating innate immune cells, such as macrophages and microglia, to study drug resistance in brain metastatic breast cancer (BMBC). The goal is to use this model to elucidate how microglia and macrophages, as well as their polarization state, influence BMBC cell phenotype and therapy response. The project will be conducted by the University of Alabama and is expected to run from September 1, 2025 to August 31, 2028. The educational and outreach plans integrated with the research include programs to engage high school students and teachers, as well as provide research opportunities for undergraduate and graduate students in cancer bioengineering.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $360.0k | 7/7/25 |