This NSF/Biological Sciences program (CFDA 47.074) award of $335,220 to the University of Texas Southwestern Medical Center supports research to characterize the structure and function of the NOSIP protein, which is involved in nuclear import and nitric oxide signaling. The project aims to understand the unique mechanism by which the nuclear import receptor TNPO1 recognizes and interacts with NOSIP, as well as how NOSIP's subcellular localization and nuclear functions are regulated by phosphorylation. The findings will provide insights into nuclear transport mechanisms and cell signaling. The project also includes an educational component to train community college students in STEM fields through hands-on lab work and development of educational resources. This collaborative effort between the Kehlenbach and Chook laboratories is supported by the National Science Foundation and the German Deutsche Forschung Gemeinschaft, with the U.S. component funded by this grant.
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