Project Grant 2454140
- The National Science Foundation Division of Chemistry awarded a $1,050,000 Project Grant to the Scripps Research Institute under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research exploring attached-ring cross-coupling chemistry and its applications. Over a three-year period from August 1, 2022 to July 31, 2025, Professor Ryan Shenvi of Scripps Research Institute will develop new non-precious metal reagents and methods for concise syntheses of...
- The National Science Foundation (NSF) Chemical Synthesis Program has awarded a $550,000 Project Grant to Professor Jon Njardarson of the University of Arizona. The grant supports the development of new asymmetric anionic reaction cascades that leverage readily available feedstock materials and negatively charged reaction partners to produce higher-value fine chemical products. Key objectives include in situ trapping of lithium enamides to expand product types, as well as the formation of...
- The National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program awarded a $550,000 project grant to Professor Hans Renata of Rice University to develop novel chemoenzymatic strategies for the synthesis of complex terpenoid natural products. The research will combine the use of engineered enzymes with modern chemical transformations to efficiently prepare a diverse range of topologically complex terpenoid molecules. The work aims to provide new insights in...
- This $574,995 federal Project Grant award was provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to the Scripps Research Institute in La Jolla, CA. The award supports Professor Ryan Shenvi's research into developing a new class of earth-abundant metal catalysts for alkene hydrofunctionalization reactions. The goal is to replace precious metal catalysts with more sustainable and cost-effective iron-based alternatives. This work aims to...
- This $575,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project led by Professors Keary Engle of the Scripps Research Institute and Peng Liu of the University of Pittsburgh. The project focuses on developing new chemical reactions using earth-abundant nickel catalysts to efficiently synthesize valuable compounds, including medicinally relevant molecules, agrochemicals, and functional...
- This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
- This $575,000 Project Grant award from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Berkeley will support Professor Thomas Maimone's research on developing new synthetic strategies for constructing complex, nitrogen-containing molecules. The work aims to identify transformations that can efficiently produce unique target molecules with potential applications in pharmaceuticals, agrochemicals, and materials. The...
- The National Science Foundation (NSF) awarded a $600,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Yale University. This 3-year grant, effective June 1, 2025, supports the development of artificial intelligence-based tools to predict the yield of chemical reactions and design synthetic routes to complex natural products, with a focus on diterpenoid compounds. The goal is to apply computational strategies to streamline and expedite the synthesis of...
- The National Science Foundation (NSF) awarded a $513,894 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to Tufts University. This 3-year grant, effective July 1, 2023, supports Professor Clay S. Bennett's research to develop new methods for synthesizing deoxy sugars - an important component of many biologically active natural products. The project aims to expand upon approaches that activate sugar hemiacetals as glycosyl sulfonates or tert-butyldimethylsilyl...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
The National Science Foundation (NSF) awarded a $549,996 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the Scripps Research Institute to study the chemical synthesis and modification of new anti-fungal and anti-malarial medicines. The grant supports Professor Ryan Shenvi's work to develop an integrated experimental and computational workflow to identify chemical characteristics and reactions needed to adapt the naturally-occurring compound siccanin into a human therapeutic. This research aims to avoid traditional trial-and-error approaches and leverage pattern recognition and quantum mechanical calculations to predict suitable molecular features. The project also includes continuing to advance Shenvi's chemistry education game, Synthordle, which allows students to practice synthetic chemistry skills through a Wordle-like format.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $145.0k | 8/28/25 | ||
| Not listed | $405.0k | 8/26/25 |