Project Grant 2451263
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $522,131.00 to New York University (NYU) from August 1, 2023 to July 31, 2026. The funded research aims to understand the relationship between RNA sequence features and splicing outcomes, as well as the role that nuclear speckles play in RNA splicing decisions. The project will leverage high-throughput assays and interpretable machine learning to identify sequence-encoded...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the agency's Biological Sciences program (CFDA 47.074) provides $680,000 from August 1, 2023 to July 31, 2026 to the University of Chicago. The project aims to understand the sequences in pre-mRNA that determine which exons are removed during RNA splicing, a critical process in eukaryotic cells for generating mature messenger RNAs. The research will use high-throughput...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
- This $324,118 National Science Foundation project grant supports research to decipher RNA-based regulatory logic through interpretable machine learning models. Funded under the Mathematical and Physical Sciences program (CFDA 47.049), the three-year award to New York University will develop and apply interpretable neural networks to massive parallel reporter assay datasets. Specifically, the models aim to elucidate the splicing code that determines exon skipping and the 5'UTR code regulating...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
- The National Science Foundation (NSF) awarded a Project Grant under the Biological Sciences (CFDA 47.074) program to The Johns Hopkins University totaling $856,135. The award will fund research to develop and apply new single-molecule methods to measure protein production in individual live cells, rather than population averages. The goal is to better understand the regulatory mechanisms governing when and where protein production occurs in cells. In addition to the core research, the project...
The National Science Foundation (NSF), through its Mathematical and Physical Sciences (CFDA 47.049) federal grant program, awarded a $500,000 Project Grant to the University of California, Irvine (UCI) to investigate splicing, a fundamental cellular process that produces multiple distinct proteins from the same gene. This research aims to uncover the rules governing RNA splicing dynamics, which are essential for healthy development but linked to diseases like cancer and neurodegeneration. The project will combine advanced microscopy techniques with predictive mathematical modeling to infer molecular splicing dynamics from static, high-resolution cellular images. The research seeks to quantify the kinetic rates governing RNA fate, including co-transcriptional splicing, post-transcriptional splicing, and degradation. The award period runs from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 8/1/25 |