Project Grant 2449235
- This $199,997 federal Project Grant, awarded by the National Science Foundation's Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for rapid and accurate detection of disease-causing RNA. The collaborative research project between William Marsh Rice University and its partners will leverage mechanism-based protein engineering and electrochemical devices to generate next-generation RNA detection tools for...
- The National Science Foundation awarded a $199,999 Project Grant under the Engineering (CFDA 47.041) program to The Trustees of the University of Pennsylvania to develop a next-generation RNA detection tool for infectious disease diagnosis. The project aims to engineer a thermostable version of the CRISPR-Cas13 enzyme to improve its stability and sensitivity for field applications. By combining the enhanced Cas13 enzyme with advanced electrochemical devices, the researchers will create an...
- This $430,785 National Science Foundation (NSF) CAREER award to the Regents of the University of California at Riverside (UC Riverside), awarded under the NSF Engineering program (CFDA 47.041), is focused on developing novel CRISPR-based biosensing technologies for the ultra-accurate detection of disease-related single nucleotide polymorphisms (SNPs). The central goals of the 5-year project are to: 1) enable ultra-accurate SNP detection using a CRISPR-Cas14 biosensor, 2) design a ratiometric SNP...
- This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a bioprocessing system to isolate and purify therapeutic antibodies directly from cell culture. The $999,998 award to Athem LLC, a minority-owned small business, will enable scaling up a novel nanoparticle-based purification media and an automated prototype system. The goal is to simplify the manufacturing of biologics, reduce...
- Castag Biosciences, Inc. received a $255,730 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The award, issued on February 15, 2021 with a completion date of January 31, 2022, will support SBIR PHASE I: HIUGE POWERED CRISPR KNOCK-IN LIBRARY FOR PROTEIN TAGGING ACROSS THE HUMAN GENOME. Specifically, the funding will enable Castag Biosciences to develop a CRISPR-based library and workflow to...
- This $1,000,000.00 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to characterize the molecular mechanisms by which the bridge helix (BH) region of the CRISPR-associated (Cas) 9 and Cas12a enzymes contributes to DNA cleavage fidelity. The overarching goal is to develop error-proof variants of these genome editing tools that minimize unintended off-target DNA modifications. The award includes a sub-grant to the University...
- This $902,504 cooperative agreement from the National Science Foundation Division of Industrial Innovation under the Engineering program (CFDA 47.041) supports the development of a scalable downstream purification process for gene therapy vectors by Isolere Bio, Inc. of Durham, North Carolina. The non-chromatographic method seeks to address current inefficiencies that lead to single digit yields by utilizing a polypeptide-based reagent combining affinity capture with phase separation and...
- This $117,074 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research at Lehigh University to develop biomaterial-guided CRISPR gene editing delivery systems. The key objectives are to: Determine how peptide-based nanoparticle formulation and properties impact CRISPR ribonucleoprotein (RNP) uptake, activity, and functionality. Investigate how material charge and porosity control the temporal action of CRISPR...
- This National Science Foundation Project Grant, funded under the Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for accurate and robust detection of disease-causing RNA. The $200,000 award, effective November 1, 2024 through October 31, 2027, supports the University of Connecticut's efforts to engineer the Cas13 enzyme for enhanced thermostability, protease resistance, and target sensitivity. The...
- This Project Grant award of $968,613 from the National Science Foundation Division of Molecular and Cellular Biosciences supports research into developing a novel CRISPR synthetic biology tool for investigating and reprogramming alkaloid biosynthesis regulation in Catharanthus roseus. The award was made on March 1, 2021 to Northeastern University for work to be completed by December 31, 2024 under the Biological Sciences program (CFDA 47.074). A sub-award of $100,000 was also provided to...
This $615,550 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support the development of an innovative affinity-based purification platform for CRISPR ribonucleoproteins (RNPs). The project, titled "STERICALLY-MODULATED AFFINITY BY RNA TRIGGERS (SMART): A NOVEL TOOLBOX FOR THE PURIFICATION OF CRISPR CAS NUCLEASES," aims to create a purification toolkit that can efficiently separate and collect the most active forms of CRISPR enzyme complexes. This will make the purification process faster, more reliable, and cost-effective, thereby accelerating medical discoveries and supporting the growing bioeconomy. In addition, the project will provide hands-on training in advanced biomanufacturing and educational opportunities in STEM fields. The award was granted to North Carolina State University and has a performance period from August 1, 2025, to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $615.6k | 8/15/25 |