This $900,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the University of Colorado to study the molecular mechanisms of DNA methyltransferase 1 (DNMT1), a critical protein responsible for silencing gene expression in different cell types. The project will utilize structural biology, biochemistry, and cell biology methods to understand how DNMT1 activity is regulated by interactions with RNA and chromatin, with the goal of providing insights into gene regulation and dysregulation that can lead to disease. Additionally, the principal investigator will develop a practical learning module to integrate teaching and research and advance critical thinking for undergraduate students, including computational methods for biological data handling and visualization. The award period runs from February 1, 2025 to January 31, 2028.
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