This $400,000 Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), aims to develop a new label-free 3D imaging technology to study ciliary beating dynamics in human airway organoids. The technology, called 3D Dynamic Contrast Optical Coherence Tomography (3D DYC-OCT), will overcome limitations of current imaging methods by providing high-speed, high-resolution 3D visualization of cilia movement without the need for fluorescent labeling. This...
This Project Grant award of $1,683,996 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of a novel 3D Dynamic Contrast Optical Coherence Microscopy (3D DYC-OCM) technology. The key products and services to be delivered include: Developing a novel swept source architecture and scalable parallel imaging platform to enable 3D...
This $600,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program aims to develop an innovative Optomagnetic Twisting Cytometry (OMTC) system to quantify the dynamic viscoelastic properties of 3D tissue samples. The project will construct an optical scanning system to enable simultaneous measurements of hundreds of thousands of microparticles within a large field-of-view, advancing the understanding of the mechanical properties of live...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Nanores LLC aims to develop a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues with nanoscale precision. The key products to be delivered include: An advanced fluorescence imaging system incorporating adaptive optics and spinning disk technology to enable 3D imaging of biological samples up...
This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Lightfinder Inc. aims to develop a silicon photonic optical coherence tomography (OCT) imager for pathology diagnostics. The primary objective is to create a high-performance, portable, and cost-effective imaging solution by integrating all optical components onto a single silicon chip. The research will address key technical challenges such as achieving high...
This $200,000 National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Clarkson University will develop a novel near-infrared (NIR) mechanochemical biophotonic platform for deep-tissue biomedical imaging. The project aims to create a breakthrough technology that combines ultrasound waves and NIR light to enable high-resolution, 3D imaging of molecular and sub-cellular structures deep within the body. This approach seeks to address limitations of existing imaging...
This federal Project Grant award of $192,168, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of a miniaturized optical coherence tomography (OCT) endoscopic system. The key products to be delivered include: Validation of a low-voltage, high-speed electrowetting-based prism scanner for use in a compact, non-mechanical...
The National Science Foundation awarded a $508,000 Project Grant to The Regents of the University of Colorado under the Engineering program (CFDA 47.041) for the period of February 1, 2021 through January 31, 2026. The grant funds the research project "CAREER: DUAL-COMB PHOTOACOUSTIC MICROSCOPY WITH SUPER-RESOLUTION WAVEFRONT SHAPING" which will develop a new dual-comb photoacoustic microscopy technique using super-resolution wavefront shaping to achieve sub-diffraction limited imaging...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $300,000 EAGER (Early-Concept Grants for Exploratory Research) project grant to The Research Foundation for The State University of New York (RF SUNY) to establish near-ultraviolet (NUV) coherent anti-Stokes Raman scattering (CARS) microscopy for highly sensitive imaging of native biomolecules. This technology will be applied to develop label-free digital pathology for brain...