This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $249,987 to the Georgia Tech Research Corporation (GTRC) supports research on the structure and function of lipid antigen selection and presentation. The key objectives are to:
-
Develop new machine learning-based tools to model the specificity and atomic structures of lipid/protein complexes.
-
Apply computational biology, biophysical assays, and structural biology approaches to define the structural basis by which lipid transfer proteins participate in lipid antigen selection and editing on CD1 immunoreceptors, as well as characterize how lipid antigen repertoires are selected by lipid transfer proteins.
The research is expected to provide the mechanistic basis for understanding the specificity and selectivity of lipid/protein complexes relative to peptide/protein complexes, and further define the roles of lipid binding proteins in biology. The award also supports educational and outreach programs to improve STEM enrollment, engagement, community, and retention. The project period runs from Apr 15, 2025 to Mar 31, 2030.
Generated 3/18/25, 3:44 AM