This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The research project will develop new methods to study these essential proteins by probing them with applied mechanical force, using atomic force microscopy. The goal is to gain fundamental biophysical understanding of how membrane proteins achieve and maintain their proper structure, which could lead to advances in protein engineering, drug design, and treatments for diseases caused by malfunctioning membrane proteins. The project will also incorporate cutting-edge biophysics concepts into undergraduate and graduate courses, and create research opportunities for students from diverse backgrounds. The award period runs from March 15, 2025 to February 28, 2030.
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