The National Science Foundation (NSF) awarded a $526,873 Project Grant under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This grant, awarded on December 15, 2024, will support research to computationally simulate protein-glue-protein binding and dissociation to understand how molecular glues mediate complex formation and the effects of protein co-localization on cellular function. The project aims to characterize molecular glue spots, elucidate glue-mediated protein associations, and uncover the reasons for protein co-localization in cells. The findings will inform the design of molecular glues and protein engineering to achieve desired cellular functions, with applications in cell biology studies and pharmaceutical development. The grant will also contribute to the training of graduate and undergraduate students through a summer workshop.
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