This $1,200,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) supports the development and application of time-resolved cryo-electron microscopy (cryo-EM) techniques to study the dynamics of diverse biological molecules. The principal investigator will collaborate with three renowned scientific laboratories to apply this innovative approach to understand the functional mechanisms of several important biological systems, including RNA polymerase, a G-protein coupled receptor, and a multi-drug efflux transporter. This research aims to expand the understanding of molecular interactions in healthy and diseased states, providing new insights that can inform advancements in molecular medicine. The grant period runs from March 15, 2025 to February 29, 2028, and no sub-awards are planned under this award.
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