This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
This $395,749 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will enable researchers at Syracuse University to develop a comprehensive physics framework for understanding how cell nuclei and tissues adapt to extreme mechanical stress. The project aims to investigate the mechanisms by which cell nuclei deform and respond to compression, as well as how tissue-level forces impact chromatin organization. The...
This $462,332 National Science Foundation project grant supports research into biomechanical regulation of intranuclear elastography and gene location in single cells. The NSF Division of Civil, Mechanical, and Manufacturing Innovation awarded this funding through the Engineering program (CFDA 47.041) to The Regents of the University of Colorado on September 1, 2022 for completion by August 31, 2025. The University of Colorado will conduct fundamental research measuring gene expression and...
The National Science Foundation awarded a $501,269 Project Grant to Stanford University under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund theoretical and computational modeling of supercoiling, topology, and active fluctuations in chromosomal organization and dynamics from September 2021 through August 2024. As part of the Mathematical and Physical Sciences program's goal of strengthening the Nation's scientific enterprise through increased understanding...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $442,366 to the University of Maryland, College Park to investigate the role of active chromatin dynamics in T cell activation and differentiation. The research aims to elucidate the driving forces for chromatin patterning, its dynamical evolution, and the resulting impact on transcriptional dynamics during T cell development. The project will use quantitative...
This federal Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports research to quantify the mechanical forces inside living cells and determine how changes in these forces impact cellular behavior. The $160,000 award to Boise State University, with a project period from February 1, 2025 to January 31, 2028, aims to develop predictive tools that use mechanical forces to control cell behavior, enabling advances in tissue engineering,...
This Project Grant award of $136,600 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at William Marsh Rice University to develop advanced tools for directly visualizing, quantifying, and correlating DNA dynamics, organization, and gene activity in real-time. The project aims to overcome challenges in studying these essential processes for regulating gene expression and healthy cell function, which have been implicated in various diseases. The...