This National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation Project Grant, awarded under CFDA Program 47.041 - Engineering, will provide $399,975 from September 1, 2023 to August 31, 2026 to Colorado State University to conduct research on the effects of microgravity and mechanical deconditioning on tissues. The research aims to investigate how mechanical unloading and microgravity trigger changes in cell nuclei and gene expression, and to develop...
The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
This $320,000 federal Project Grant, awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports collaborative research between Rensselaer Polytechnic Institute (RPI) and other institutions to study crystal growth and particle self-assembly during directional solidification in microgravity conditions on the International Space Station (ISS). The research aims to reveal the subtle forces involved in growing solvent crystals and forming particle assemblies, which...
The University of California, San Diego will receive $400,000 from the National Science Foundation under the Engineering (CFDA 47.041) federal grant program to research the mechanisms of microgravity accelerated aging on human brain organoids from October 1, 2021 to September 30, 2024. Through this three-year Project Grant, UCSD researchers will study how microgravity exposure impacts the aging process in miniaturized human brain tissues grown in a laboratory, with the goal of furthering...
This $274,990 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I Project Grant, awarded under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop and advance the regulatory pathway for commercializing space-made Janus Base Nanoparticles (JBNPs) as an innovative drug delivery system for treating solid tumors. The project focuses on demonstrating the comparability of space-manufactured JBNPs to their earth-made counterparts, a...
This National Science Foundation Project Grant of $400,000 supports research at the University of Alabama at Birmingham from January 2023 through December 2025 under the Engineering program (CFDA 47.041). The award will leverage the space environment to study the molecular mechanisms by which the bacterium Streptococcus pneumoniae causes cardiac toxicity and infection. Researchers will use a cardiac tissue chip model on the International Space Station to identify critical factors that allow S....
This $420,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports collaborative research on the effects of microgravity conditions on crystal growth and particle self-assembly during directional solidification of solutions. The research aims to reveal the subtle forces involved in these processes when gravity is removed, and compare the structural features obtained in microgravity versus on Earth. The research will integrate experimental...
This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This $349,887 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of an innovative artificial intelligence (AI) technology to select optimal cancer treatment options tailored to individual patients. The goal is to prolong patient life and reduce healthcare costs by avoiding initial treatment failures. The Research Foundation for the State University of New York (RF SUNY) is the prime...
This federal Project Grant award, funded by the National Science Foundation's Engineering program (CFDA 47.041), supports research to grow three-dimensional cancer-myeloid organoids on the International Space Station (ISS) in order to better mimic brain tumor formation and study interactions between cancer and immune cells.
The $400,000 award, with a project period from September 2024 to August 2027, will first generate "flight-ready" organoid seeds from various cancer and immune cell types. These will then be sustained and grown on the ISS for up to 45 days, and analyzed upon return to derive novel insights into the "immunomechanical" signatures of the microgravity environment compared to ground controls. The research aims to advance fundamental knowledge of brain cancer that can inform future interventions. The project also includes plans for outreach and training the next generation of space scientists and engineers.