Project Grant 2223072
- This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...
- This $400,000 Project Grant, awarded November 1, 2025, through the National Science Foundation (NSF) Engineering program (CFDA 47.041), funds research to elucidate integrin mechanotransduction mechanisms in microgravity environments. Emory University's Office of Sponsored Programs will develop and deploy molecular tension fluorescence microscopy probes based on DNA hairpins and duplexes to quantify integrin forces aboard the International Space Station (ISS). The research addresses how cells...
- The Trustees of Princeton University, Office of Research and Project Administration, received a $340,033 project grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the NSF Engineering directorate program (CFDA 47.041). The project, titled "ISS: The Influence of Microgravity on Bacterial Transport and Pellicle Morphogenesis," investigates the formation and growth of pellicles - bacterial communities that...
- The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
- This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
- The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
- This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
- This $599,486 National Science Foundation award under the Engineering (47.041) program will fund the development of an engineered cardiac tissue model with embedded soft microelectronics for continuous cardiotoxicity screening at The Pennsylvania State University from January 2022 to September 2023. The key product is a 3D-bioprinted, microvascularized cardiac tissue model integrated with stretchable microelectronics to enable real-time, intra-tissue measurement of cardiotoxicity responses to...
- This $449,582 National Science Foundation project grant funds research at Virginia Polytechnic Institute and State University from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to understand the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, structural changes in capillary network formation...
This National Science Foundation Project Grant of $400,000 supports research at the University of Alabama at Birmingham from January 2023 through December 2025 under the Engineering program (CFDA 47.041). The award will leverage the space environment to study the molecular mechanisms by which the bacterium Streptococcus pneumoniae causes cardiac toxicity and infection. Researchers will use a cardiac tissue chip model on the International Space Station to identify critical factors that allow S. pneumoniae to overcome antibiotic treatment and damage heart tissue. The project aims to exploit unique phenomena in microgravity to gain insights into molecular signaling pathways associated with S. pneumoniae infection progression and cardiac dysfunction. It also provides training for graduate and undergraduate students, incorporating research outcomes into STEM course modules. Insights gained could help identify early therapeutic targets to prevent adverse cardiac events from S. pneumoniae infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 7/25/22 |