This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $154,000 in funding to Boston University from July 1, 2024 to June 30, 2027 to conduct research on protein aggregation and liquid-liquid phase separation (LLPS). The project, a collaborative effort between US and French researchers, aims to elucidate how protein-rich droplets can promote the pathological aggregation of proteins associated with neurodegenerative diseases,...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $125,896 to Western Washington University to conduct research on intrinsically disordered proteins (IDPs). The project aims to bridge time and length scales of IDP conformations and assemblies using advanced computational methods. Key goals include characterizing the conformational landscape of IDPs, elucidating factors leading to phase separation, and developing...
The National Science Foundation (NSF) awarded a $100,000 Project Grant to Rutgers, The State University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The 3-year grant supports a collaborative U.S.-France research project to develop new experimental and analytical methods for probing the heterogeneity of biological systems at the molecular level. Key deliverables include: 1) advanced high-speed atomic force spectroscopy techniques to study the complex structural...
This $350,000 federal Project Grant was awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The goal of the research is to develop accurate mathematical models and computer simulations for studying non-equilibrium systems with memory effects, such as those found in biosystems, plasma evolution, and solid-state nanostructures. The Principal Investigator will focus on analytical and numerical approaches to statistical transport...
This $780,644 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) aims to investigate the relationship between protein phase separation, aggregation, and the age-dependency of human diseases. The research will leverage comprehensive libraries of disease-associated protein mutations to define how phase separation and aggregation processes contribute to the onset and progression of age-related diseases. Key objectives include: Defining the phase...
This is a $600,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Davis. The award supports research investigating the fundamental mechanisms underlying liquid-liquid phase separation and membrane remodeling in cell-like environments. The project aims to quantify the dynamics of phase coarsening, map relationships between intravesicular macromolecular crowding and membrane changes, and...
This Project Grant award, funded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research at Louisiana State University (LSU) to investigate the interactions between proteins and polysaccharides (complex sugars) in crowded cellular environments. The $354,932 award, with a project period from April 1, 2025 to March 31, 2030, aims to uncover the molecular mechanisms driving phase separation between these biomacromolecules and understand the...
This $306,532 federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will fund research at Yale University to investigate the role of molecular motions in the allosteric activation of the enzyme imidazole glycerol phosphate synthase. The project will utilize advanced field cycling nuclear magnetic resonance spectroscopy techniques, coupled with computational modeling, to gain unprecedented insights into the timescales and...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the phase behavior of proteins in crowded cellular environments. The $441,108 award, spanning from Sep 2024 to Aug 2027, will enable researchers at Louisiana State University to: 1) Study the effects of molecular crowding on the phase transition of model protein/polymer systems; 2)...