This $154,000 Project Grant, awarded on July 1, 2024 by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), supports collaborative research between US and French scientists to investigate the role of liquid-liquid phase separation (LLPS) in protein aggregation associated with neurodegenerative diseases. The key objectives are to elucidate the basic properties of protein-rich droplets and the processes leading to droplet formation that can promote pathological protein aggregation, with a focus on the intrinsically disordered proteins tau and alpha-synuclein. The project will employ a multidisciplinary approach combining experimental techniques such as electron paramagnetic resonance, nuclear magnetic resonance, and neutron scattering with advanced computational modeling. The award also enables the exchange of junior researchers between the US and French partner institutions to support their professional development. No subawards are planned under this grant.
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